Mitogen activated protein kinase phosphatase cDNAS and their bio

Details Mitogen activated protein kinase phosphatase cDNAS and their bio Mitogen activated protein kinase phosphatase cDNAS and their bio

1997-12-15

1999-12-07

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C12N 916

Patent

active

059981881

ABSTRACT:
The invention relates to a novel mitogen-activated protein kinase phosphatase, MKP-2. The invention further relates to methods and means for preparing and to nucleic acids encoding this protein. The MKP-2 of the present invention is useful in the control of cell growth, differentiation and apoptosis.

REFERENCES:
patent: 5512434 (1996-04-01), Aaronson et al.
Pages, G., et al., "Mitogen-activated protein kinases p42.sup.mapk and p44.sup.mpak are required for fibroblast proliferation," Proc. Natl. Acad. Sci. U.S.A. 90:8319-8323 (1993).
Blenis, J., "Signal Transduction via the MAP kinases: Proceed at your own Risk," Proc. Natl. Acad. Sci. U.S.A. 90:5889-5892 (1993).
Cowley, S. et al., "Activation of MAP Kinase Kinase Is Necessary and Sufficient for PC12 Differentiation and for Transformation of NIH 3T3 Cells," Cell 77:841-852 (1994).
Chao, M.V., "Growth Factor Signaling: Where Is The Specificity," Cell 68:995-997 (1992).
Nguyen, T.T. et al., "Co-regulation of the Mitogen-activated Protein Kinase, Extracellular Signal-Regulated Kinase 1, and the 90-kDa Ribosomal S6 Kinase in PC12 Cells," Biol. Chem. 268:9803-9810 (1993).
Wood, K.W. et al., "ras Mediates Nerve Growth Factor Receptor Modulation of Three Signal-Transducing Protein Kinases: MAP Kinase, Raf-1, and RSK," Cell 68:1041-1050 (1992).
Alema, S. et al., "Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene," Nature 316:557-559 (1985).
Thomas, S.M. et al., "Ras Is Essential for Nerve Growth Factor-and Phorbol Ester-Induced Tyrosine Phosphorylation of MAP Kinases," Cell 68:1031-1040 (1992).
Thomas, S.M. et al., "Induction of Neurite Outgrowth by v-src Mimics Critical Aspects of Nerve Growth Factor-Induced Differentiation," Mol. Cell. Biol. 11:4739-4750 (1991).
Lloyd, E.D. et al., ".sup.pp42/44 MAP Kinase Is a Component of the Neurogenic Pathway Utilized by Nerve Growth Factor in PC12 Cells," J. Neurochem. 59:1099-1109 (1992).
Crews, C.M. et al., "Extracellular Signals and Reversible Protein Phosphorylation: What to Mek of It All," Cell 74:215-217 (1993).
Zheng, C.-F. et al., "Protein of MEKs, the Kinases That Phosphorylate and Activate the Extracellular Signal-regulated Kinases," J. Biol. Chem. 268:23933-23939 (1993).
Sun, H. et al., "MKP-1 (3CH134), an Immediate Early Gene Product, Is A Dual Specificity Phosphatase That Dephosphorylates MAP Kinase In Vivo," Cell 75:487-493 (1993).
Alessi, D.R. et al., "The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts," Oncogene 8:2015-2020 (1993).
Ward, Y. et al., "Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1," Nature 367:651-654 (1994).
Zheng, C.-F. et al., "Dephosphorylation and Inactivation of the Mitogen-activated Protein Kinase by a Mitogen-induced Thr/Tyr Protein Phosphatase," J. Biol. Chem. 268:16116-16119 (1993).
Traverse, S. et al., "Sustained activation of the mitogen-activated protein (MAP) kinase cascade made by required for differentiation of PC12 cells," Biochem. J. 288:351-355 (1992).
Kumagai, A. et al., "Regulation of the cdc25 Protein during the Cell Cycle in Xenopus Extracts," Cell 70:139-151 (1992).
Charles, C.H. et al., "cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein," Oncogene 7:187-190 (1992).
Doi, K. et al., "MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae," EMBO J. 13:61-70 (1994).
Guan, K. et al., "Cloning and expression of a protein-tyrosine-phosphatase," Proc. Natl. Acad. Sci. U.S.A. 87:1501-1505 (1990).
Keyse, S.M. et al., "Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase," Nature 359:644-647 (1992).
Rohan, P.J. et al., "PAC-1: A Mitogen-Induced Nuclear Protein Tyrosine Phosphatase," Science 259:1763-1766 (1993).
Ishibashi, T. et al., "A Novel Dual Specificity Phosphatase Induced By Serum Stimulation and Heat Shock," J. Biol. Chem. 269:29897-29902 (1994).
Sun, H. et al., "Inhibition of Ras-Induced DNA Synthesis by Expression of the Phosphatase MKP-1," Science 266:285-288 (1994).
Noguchi, T. et al., "Structure, Mapping, and Expression of erp, a Growth FActor-Inducible Gene Encoding a Nontransmembrane Protein Tyrosine Phosphatase, and Effect of ERP on Cell Growth," Mol. Cell. Biol. 13:5195-5205 (1993).
Boulton, T.G. et al., "ERKs: A Family of Protein-Serine/Tyreonine Kinases That Are Activated and Tyrosine Phosphorylated in Response to Insulin and NGF," Cell 65:663-675 (1991).
Thomas, K.R. et al., "Swaying Is a Mutant Allele of the Proto-Oncogene Wnt-1," Cell 67:969-976 (1991).
Druker, B. et al., "Tyrosine Phophorylation of rasGAP and Associated Proteins in Chronic Myelogenous Leukemia Cell Lines," Blood 79:2215-2220 (1992).
Sanger, F. et al., "DNA sequencing with chain-terminating inhibitors," Proc. Natl. Acad. Sci. U.S.A. 74:5463-5467 (1977).
Misra-Press, A. et al., "Complex Alternative Splicing Partially Inactivates the Human Chorionic Somatomammoropin-like (hCS-L) Gene," J. Biol. Chem. 269:23220-23229 (1994).
Arriza, J.L. et al., "The Neuronal Mineralocorticoid Receptor as a Mediator of Glucocorticoid Response," Neuron 1:887-900 (1988).
Bruder, J.T. et al., "Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf1 kinase," Genes & Develop. 6:545-556 (1992).
Howley, P.M. et al., "Eukaryotic Cloning Vectors Derived from Bovine Papillomavirus DNA," Methods Enzymol. 101:387-402 (1983).
Luehrsen, K.R. et al., "Transient Expression Analysis in Plants Using Firefly Luciferase Reporter Gene," Methods Enzymol. 216:397-414 (1992).
Bradford, M.M., "A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding," Anal. Biochem. 72:248-254 (1976).
Bialojan, C. et al., "Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases," Biochem J. 256:283-290 (1988).
MacKintosh, C. et al., "Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants," FEBS Lett. 264:187-192 (1990).
Marais, R. et al., "The SRF Accessory Protein Elk-1 Contains a Growth Factor-Regulated Transcriptional Activation Domain," Cell 73:381-393 (1993).
Kwak, S.P. et al., "Isolation and Chracterization of a Human Dual Specificity Protein-Tyrosine Phosphatase Gene," J. Biol. Chem. 269:3596-3604 (1994).
Shaw, G. et al., "A Conserved AU Sequence from the 3' Untranslated Region of GM-CSF mRNA Mediates Selective mRNA Degradation," Cell 46:659-667 (1986).
Fiore, R.S. et al., "p42 Mitogen-Activated Protein Kinase In Brain: Prominent Localization In Neuronal Cell Bodies And Dendrites," Neurosci. 55:463-472 (1993).
Boulton, T.G. et al., "ERKs: A Family Of Protein-Serine/Threomine Kinases That Are Activated And Tyrosine Phosphorylated In Response To Insulin And NGF," Cell 65:663-675 (1991).
Bading, H. et al., "Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation," Science 253:912-914 (1991).
Friedman, L.K. et al., "Kainate-induced Status Epilepticus Alters Glutamate and GABA.sub.A Receptor Gene Expression in Adult Rat Hippocampus: An in situ Hybridization Study," J. Neurosci. 14:2697-2707 (1994).
Pennypacker, K.R. et al., "Kainate-Induced Changes in Opioid Peptide Genes and AP-1 Protein Expression in the Rat Hippocampus," J. Neurochem. 60:204-211 (1993).
Derijard, B. et al., "JNK1: A Protein Kinase Stimulated by UV Light and Ha-Ras That Binds and Phosphorylates the c-Jun Activation Domain," Cell 76:1025-1037 (1994).
Loeb, D.M. et al., "A Trk Nerve Growth Factor (NGF) Receptor Point Mutation Affecting Interaction with Phospholipase C-.tau.1 Abolishes NFG-promoted Peripherin Induction but Not Neurite Outgrowth," J. Biol. Chem. 269:8901-8910 (1994).
Young, S.W. et al., "Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase," FEBS Lett. 338:212-216 (1994).
Wu, J. et al., "Rapid deac

Affiliated with

Also associated with

Rating

Mitogen activated protein kinase phosphatase cDNAS and their bio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mitogen activated protein kinase phosphatase cDNAS and their bio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mitogen activated protein kinase phosphatase cDNAS and their bio will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-822668