Mitogen-activated protein kinase p38-2 and methods of use theref

Details Mitogen-activated protein kinase p38-2 and methods of use theref Mitogen-activated protein kinase p38-2 and methods of use theref

1996-05-20

1999-09-07

Huff, Sheela

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530352, 536 235, 435 76, A61K 3800, A61K 3816, C07H 2104, G01N 3353

Patent

active

059488859

ABSTRACT:
Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

REFERENCES:
Han et al., "A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells," Science 265: 808-811, 1994.
Lee et al., "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis," Nature 372: 739-746, 1994.
Derijard et al., "JNK1: A Protein Kinase Stimulated by UV Light and Ha-Ras That Binds and Phosphorylates the c-Jun Activation Domain," Cell 76: 1025-1037, 1994.
Gupta et al., "Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway," Science 267:389-393, 1995.
Lin et al., "Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2," Science 268: 286-290, 1995.
Davis, R. "MAPKs: new JNK expands the group," TIBS 19: 470-473, 1994.
Cano and Mahadevan, "Parallel signal processing among mammalian MAPKs," TIBS 20: 117-122, 1995.
Derijard et al., "Independent Human MAP Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms," Science 267:682-685, 1995.
Yashar et al., "Novel Members of the Mitogen-Activated Protein Kinase Activator Family in Xenopus laevis," Molecular and Cellular Biology 13(9):5738-5748, 1993.
Herskowitz, I., "MAP Kinase Pathways in Yeast: For Mating and More," Cell 80:187-197, 1995.
Yan et al., "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1," Nature 372: 798-800, 1994.
Seger and Krebs, "The MAPK signaling cascade," FASEB Journal 9:726-735, 1995.
Rouse et al., "A Novel Kinase Cascade Triggered by Stress and Heat Shock That Stimulates MAPKAP Kinase-2 and Phosphorylation of the Small Heat Shock Proteins," Cell 78:1027-1037, 1994.
Pang et al., "Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor," Journal of Biological Chemistry 270(23): 13585-13588, 1995.
Moriguchi et al., "Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases. Existence of Novel Activators," Journal of Biological Chemistry 270(22): 12969-12972, 1995.
Minden et al., "Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK," Science 266: 1719-1723, 1994.
Cobb et al., "Extracellular signal-regulated kinases: ERKs in progress," Cell Regulation 2: 965-977, 1991.
Zhou et al., "Components of a New Human Protein Kinase Signal Transduction Pathway," Journal of Biological Chemistry 270(21): 12665-12669, 1995.
Cobb and Goldsmith, "How MAP Kinases Are Regulated," Journal of Biological Chemistry 270(25): 14843-14846, 1995.
Hunter and Karin, "The Regulation of Transcription by Phosphorylation," Cell 70:375-387, 1992.
Hunter, T., "Protein Kinases and Phosphatases: The Yin and Yang of Protein Phosphorylation and Signaling," Cell 80:225-236, 1995.
Karin and Smeal, "Control of transcription factors by signal transduction pathways: the beginning of the end," TIBS 17: 418-422, 1992.
Sanchez et al., "Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun," Nature 372:794-798, 1994.
Han et al, "Molecular cloning of human p38 MAP kinase" Biochimica et Biophysica Acta, vol. 1265, pp. 224-227, Mar. 16, 1995.
Jiang et al., "Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38.beta.)," The Journal of Biological Chemistry 271(30):17920-17926, 1996.
Kumar et al., "Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitiviy to Inhibition by Pyridinyl Imidazoles," Biochemical and Biophysical Research Communications 235:533-538, 1997.
Li et al., "The Primary Structure of p38.gamma.: A New Member of p38 Group of MAP Kinases," Biochemical and Biophysical Research Communications 228:334-340, 1996.
Nahas et al., "Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists," Biochem. J. 318:247-253, 1996.

Affiliated with

Also associated with

Rating

Mitogen-activated protein kinase p38-2 and methods of use theref does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mitogen-activated protein kinase p38-2 and methods of use theref, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mitogen-activated protein kinase p38-2 and methods of use theref will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1805368