Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Reexamination Certificate
2007-04-10
2007-04-10
Rao, Manjunath (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
C435S004000, C435S006120, C435S069100, C435S183000, C435S194000, C435S252300, C435S320100, C536S023200, C536S023740, C536S023400, C530S350000
Reexamination Certificate
active
10197315
ABSTRACT:
Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
REFERENCES:
patent: 5948885 (1999-09-01), Stein et al.
patent: 6074862 (2000-06-01), Stein et al.
patent: 6444455 (2002-09-01), Stein et al.
patent: 6677130 (2004-01-01), Stein et al.
patent: WO 95/07922 (1995-03-01), None
patent: WO 95/21923 (1995-08-01), None
patent: WO 96/36642 (1996-11-01), None
Adams et al. GenBank Acc No. AAR71677, Oct. 22, 1995.
Ben-Levy et al. 1995. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. EMBO J. 14(23):5920-30.
Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248-54.
Cano and Mahadevan. 1995. Parallel signal processing among mammalian MAPKs. Trends Biochem Sci. 20(3):117-22.
Cobb and Goldsmith. 1995. How MAP Kinases Are Regulated. Journal of Biological Chemistry 270(25):14843-14846.
Cobb et al. 1991. Extracellular Regulated Kinases: ERKs in Progress. Cell Regulation 2:965-977.
Cobb et al. 1991.Extracellular signal-regulated kinases: ERKs in progress, Cell Regulation 2: 965-977.
Davis R. 1994. MAPKs: New JNK expands the group. Trends Biochem Sci. 19:470-473.
Derijard et al. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76(6):1025-37.
Derijard et al. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science. 267(5198):682-5.
Fraley et al. 1981. Trends Biochem. Sci. 6:77-80.
Gupta et al. 1995. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science. 267(5196):389-93.
Han et al, Molecular cloning of human p38 MAP kinase. Biochimica et Biophysica Acta, vol. 1265, pp. 224-227, Mar. 16, 1995.
Han et al. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 265(5173):808-11.
Han et al. BBA, 1995, vol. 1265:224-227.
Han et al. GenBank Acc. No. S53536, Jul. 15, 1995.
Herskowitz I. 1995. MAP kinase pathways in yeast: for mating and more. Cell. 80(2):187-97.
Hunter and Karin. 1992. The Regulation of Transcription by Phosphorylation. Cell 70:375-387.
Hunter T. 1995. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell. 80(2):225-36.
Jiang et al. 1996. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem. 271(30):17920-6.
Karin and Smeal. 1992. Control of transcription factors by signal transduction pathways: the beginning of the end. Trends Biochem Sci. Oct. 1992;17(10):418-22.
Kawai and Nishizawa. 1984. New procedure for DNA transfection with polycation and dimethyl sulfoxide. Mol Cell Biol. 4(6):1172-4.
Kohler G, and Milstein C. 1976. Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur J Immunol. 6(7):511-9.
Kumar et al. 1997. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 235(3):533-8.
Lee et al. 1994. A protein kinase involved in the regulation of inflammAtory cytokine biosynthesis. Nature. 372(6508):739-46.
Li et al. 1996. The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun. 228(2):334-40.
Lin et al. 1995. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 268(5208):286-90.
Mannino RJ, and Gould-Fogerite S. 1988. Liposome mediated gene transfer. Biotechniques. 6(7):682-90.
McLaughlin et al. 1996.Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel structure of CSBP p38 MAP kinase. J Biol Chem. 271(14):8488-92.
McNalley et al. 1988. Optimizing electroporation parameters for a variety of human hematopoietic cell lines. Biotechniques. 6(9):882-6.
Minden et al. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science. 266(5191):1719-23.
Moriguchi et al. 1995. Evidence for multiple activators for stress-activated protein kinase/c-Jun amino-terminal kinases. Existence of novel activators. J Biol Chem. 270(22):12969-72.
Nahas et al. 1996.Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists. Biochem J. 318 ( Pt 1):247-53.
Pang et al. 1995. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem. 270(23):13585-8.
Rouse et al. 1994. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 78(6):1027-37.
Rouse et al. GenBank Accession No. A54805, Oct. 28, 1994.
Sanchez et al. 1994. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 372(6508):794-8.
Seger and Krebs. 1995. The MAPK signaling cascade. FASEB J. 9(9):726-35.
Ulmer et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 259(5102):1745-9.
Yamaguchi et al. 1995. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 270(5244):2008-11.
Yan et al. 1994. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature. 372(6508):798-800.
Yashar et al. 1993. Novel members of the mitogen-activated protein kinase activator family inXenopus laevis. Mol Cell Biol. 13(9):5738-48.
Zhou et al. 1995. Novel members of the mitogen-activated protein kinase activator family inXenopus laevis. Mol Cell Biol. Sep. 1993;13(9):5738-48.
Zhou et al., Components of a New Human Protein Kinase Signal Transduction Pathway. Journal of Biological Chemistry 270(21):12665-12669,1995.
Stein Bernd
Yang Maria X. H.
Young David B.
Jones Day
Rao Manjunath
Signal Pharmaceuticals Inc.
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