Mitogen-activated protein kinase kinase MEK6 and variants thereo

Details Mitogen-activated protein kinase kinase MEK6 and variants thereo Mitogen-activated protein kinase kinase MEK6 and variants thereo

1995-12-20

2000-06-13

Feisee, Lila

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

530350, 424 941, C12N 912

Patent

active

060748621

ABSTRACT:
Compositions and methods are provide for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

REFERENCES:
patent: 5736381 (1998-04-01), Davis et al.
Raingeaud et al., Mol. Cell. Biol., 16(3): 1247-1255, Mar. 1996.
Darnel et al., Molecular Cell Biology, Scientific American Books: New York, NY, p. 54, 1986.
Han et al., "A MAP Kinase Targeted by Endotoxin and Hypersmolarity in Mammalian Cells," Science 265: 808-811, 1994.
Derijard et al., "Independent Human MAP Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms," Science 267: 682-685, 1995.
Yashar et al., "Novel Members of the Mitogen-Activated Protein Kinase Activator Family in Xenopus laevis," Molecular and Cellular Biology 13(9); 5738-5748, 1993.
Cano and Mahadevan, "Parallel signal processing among mammalian MAPKs," Trends in Biochemical Sciences 20: 117-122, 1995.
Lee et al., "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis," Nature 372: 739-746, 1994.
Lin et al., "Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2," Science 268: 286-290, 1995.
Herskowitz, I., "MAP Kinase Pathways in Yeast: For Mating and More," Cell 80: 187-197, 1995.
Yan et al., "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1," Nature 372: 798-800, 1994.
Seger and Krebs, "The MAPK signaling cascade," FASEB Journal 9: 726-735, 1995.
Rouse et al., "A Novel Kinase Cascade Triggered by Stress and Heat Shock That Stimulates MAPKAP Kinase-2 and Phosphorylation of the Small Heat Shock Proteins," Cell 78: 1027-1037, 1994.
Pang et al., "Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor," Journal of Biological Chemistry 270(23): 13585-13588, 1995.
Moriguchi et al., "Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases. Existence of Novel Activators," Journal of Biological Chemistry 270(22): 12969-12972, 1995.
Davis, r. "MAPKs: new JNk expands the group," Trends in Biochemical Sciences 19: 470-473, 1994.
Minden et al., "Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK," Science 266: 1719-1723, 1994.
Cobb et al., "Extracellular signal-regulated kinases; ERKs in progress," Cell Regulation 2: 965-978, 1991.
Zhou et al., "Components of a New Human Protein Kinase Signal Transduction Pathway," Journal of Biological Chemistry 270(21): 12665-12669, 1995.
Cobb and Goldsmith, "How MAP Kinases Are Regulated," Journal of Biological Chemistry 270(25): 14843-14846, 1995.
Hunter and Karin, "The Regulation of Transcription by Phosphorylation," Cell 70: 375-387, 1992.
Hunter, T., "Protein Kinases and Phosphatases: The Yin and Yang of Protein Phosphorylation and Signalig," Cell 80: 225-236, 1995.
Karin and Smeal, "Control of transcription factors by signal transduction pathways: the beginning of the end," Trends in Biochemical Sciences 17: 418-422, 1992.
Sanchez et al., "Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun," Nature 372: 794-798, 1994.
Crystal, R. Science. vol. 270: pp. 404-410, Oct. 20, 1995.
Cuenda et al., "Purification and cDNa cloning of SAPKK3, the major activator of RK/p38 in stress-and cytokine-stimulated monocytes and epithelial cells," EMBO Journal 15(16): 4156-4164, 1996.
Han et al., "Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)," Journal of Biological Chemistry 271(6): 2886-2891, 1996.
Stein et al., "Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade," Journal of Biological Chemistry 271(19): 11427-11423, 1996.

Affiliated with

Also associated with

Rating

Mitogen-activated protein kinase kinase MEK6 and variants thereo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mitogen-activated protein kinase kinase MEK6 and variants thereo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mitogen-activated protein kinase kinase MEK6 and variants thereo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2067622