Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-11-17
2000-04-25
LeGuyader, John L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435194, C07K 1640
Patent
active
060545607
ABSTRACT:
An isolated c-Fos regulating kinase polypeptide (FRK) characterized by having a molecular weight of 88 kD as determined by reducing SDS-PAGE, having threonine and serine kinase activity, phosphorylating the c-Fos activation domain and polynucleotide sequences and method of detection of FRK are provided herein. Also described are methods for identifying compositions which affect FRK activity, thereby affecting c-Fos activation and subsequent activation of genes associated with AP-1 sites.
REFERENCES:
patent: 5605808 (1997-02-01), Karin et al.
Bannister et al, Nucleic Acid Res., 22, 5173-5176, 1994.
Chen et al, Proc. Natl. Acad. Sci. USA, 90, 10952-10956, 1993.
Deng et al., "C-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK", Nature, 371:171-175, 1994.
Taylor et al., "Identification of a nerve growth factor--and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos", Proc. Natl. Acad. Sci., USA, 90:368-37, 1993.
Richard A. Lerner, Tapping the immunological repertoire to produce to produce antibodies of predetermined specificity Nature, 299:592-596, 1982.
Deng Tiliang
Karin Michael
Haile Lisa A.
LeGuyader John L.
The Regents of the University of California
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