Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-09-09
1998-11-17
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 15, C12Q 148, C12Q 168
Patent
active
058374515
ABSTRACT:
An isolated c-Fos regulating kinase polypeptide (FRK) characterized by having a molecular weight of 88 kD as determined by reducing SDS-PAGE, having threonine and serine kinase activity, phosphorylating the c-Fos activation domain and polynucleotide sequences and method of detection of FRK are provided herein. Also described are methods for identifying compositions which affect FRK activity, thereby affecting c-Fos activation and subsequent activation of genes associated with AP-1 sites.
REFERENCES:
patent: 5605808 (1997-02-01), Karin et al.
Deng et al., "c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK", Nature, 371:171-175, 1994.
Taylor et al., "Identification of a nerve growth factor--and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos", Proc. Natl. Acad. Sci.. USA, 90:368-372, 1993.
Richard A. Lerner, Tapping the immunological repertoire to produce antibodies of predetermined specificity, Nature, 299:592-596, 1982.
Bannister et al, Nucleic Acid Res., 22, 5173-5176, 1994.
Chen et al Proc. Natl. Acad. SCI. USA, 90 10952-10956, 1993.
Deng Tiliang
Karin Michael
Saunders David
The Regents of the University of California
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