Mitogen activated c-Fos regulating kinase, FRK

Details Mitogen activated c-Fos regulating kinase, FRK Mitogen activated c-Fos regulating kinase, FRK

1996-09-09

1998-05-05

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

424 946, 424 9461, C12N 912, A61K 3846, A61K 3847

Patent

active

057473188

ABSTRACT:
An isolated nitrogen activated c-Fos regulating kinase polypeptide (FRK) having a molecular weight of about 88-kD as determined by reducing SDS-PAGE, having threonine and serine kinase activity, phosphorylating the c-Fos activation domain at amino acid residue Thr 232 and having polynucleotide sequences and a method of detection for FRK are provided herein. Also described are methods for identifying compositions which affect FRK activity, thereby affecting c-Fos activation and subsequent activation of genes associated with AP-1 sites.

REFERENCES:
Deng, et al., c-Fos transcriptional activity stimulated by H-Ras- activated protein kinase distinct from JNK and ERK, Nature, 371: 171-175, 1994.
Richard A. Lerner, Tapping the immunological repertoire to produce antibodies of predetermined specificity, Nature, 299: 592-596, 1982.
Taylor et al. "Identification of a nerve growth factor- and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos" Proc. Nat. Acad. Sci., USA (Jan. 1993) vol. 90, pp. 368-372.
Barber et al. "Proto-oncogene Fos: factors affecting expression and covalent modication of the gene product" Annals NY Acad. Sci. (1987) vol. 511, pp. 117-130.
Nel et al. "Activation of a novel serine/threonine kinase tht phosphorylates c-Fos upon stimulation of T and B lymphocytes via antigen and cytokine receptors" J. Immunol. (1994) vol. 152, pp. 4347-4357.

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