Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1997-07-17
1999-02-09
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4352523, 43525233, 43525411, 4352543, 435325, 435419, 4353201, 536 231, 536 232, C12N 1509, C12N 914, C07K 14435
Patent
active
058693114
ABSTRACT:
The invention provides a human mitochondrial processing peptidase subunit (MPPS-1) and polynucleotides which identify and encode MPPS-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of MPPS-1.
REFERENCES:
Kitada S, et al., Molecular cloning of the smaller subunit (P52) of rat liver mitochondrial processing protease. Biochem Biophys Res Commun. 1993 Jan 15; 190(1:289-293, Jan. 15, 1993.
Kalousek F, et al. Uniform nomenclature of the mitochondrial peptidases cleaving precursors of mitochondrial proteins. Trends Biochem Sci. 1993 Jul; 18(7): 249, Jul. 1, 1993.
Niidome T, et al. Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate. J Biol Chem. 1994 Oct 7; 269(40): 24719-24722, Oct. 7, 1994.
Kitada S, et al. A putative metal-binding site in the beta subunit of rat mitochondrial processing peptidase is essential for its catalytic activity. J Biochem (Tokyo), 1995 Jun; 117(6): 1148-1150, Jun. 1, 1996.
Rawlings ND, et al. Homologues of insulinase, a new superfamily of metalloendopeptidases. Biochem J. 1991 Apr. 15; 275(Pt 2): 389-391, Apr. 15, 1991.
Paces, V. et al, "The .beta. subunit of the mitochondrial processing peptidase from rat liver: Cloning and sequencing of a cDNA and comparison with a proposed family of metallopeptidases." Proc. Natl. Acad. Sci. USA (1993) 90:5355-5358 (GI 294589).
Hoffman, G.G. et al., "Complete Coding Sequence, Intron/Exon Organization, and Chromosomal Location of the Gene for the Core I Protein of Human Ubiquinol-Cytochome c Reductase." J. Biol. Chem. (1993) 268:21113-21119. (GI 1082896).
Kleiber, J. et al., "The general mitochondrial matrix processing protease from rat liver: Structural characterization of the catalytic subunit." Proc. Natl. Acad. Sci. USA (1990) 87:7978-7982.
Paces, V. et al., (GI 2984589) GenBank Sequence Database (Accession L12965), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No year provided.
Paces, V. et al., (GI 294588) GenBank Sequence Database (Accession L12965), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No year provided.
Hoffman, G.G. et al., (GI 1082896) GenBank Sequence Database (Accession A48043), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No year provided.
Hoffman, G.G. et al., (GI 349472) GenBank Sequence Database (Accession L16842), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No. year provided.
Bandman Olga
Corley Neil C.
Shah Purvi
Billings Lucy J.
Hendricks Keith D.
Incyte Pharmaceuticals Inc.
Mayhew Bradley S.
Mohan-Peterson Sheela
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