Mitochondrial processing peptidase subunit

Details Mitochondrial processing peptidase subunit Mitochondrial processing peptidase subunit

1999-01-22

1999-12-14

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, C12N 964

Patent

active

060016299

ABSTRACT:
The invention provides a human mitochondrial processing peptidase subunit (MPPS-1) and polynucleotides which identify and encode MPPS-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of MPPS-1.

REFERENCES:
Paces, V. et al., "The .beta. subunit of the mitochondrial processing peptidase from rat liver: Cloning and sequencing of a cDNA and comparison with a proposed family of metallopeptidases." Proc.Natl.Acad.Sci.USA (1993) 90:5355-5358. (GI 294589).
Hoffman, G.G. et al., "Complete Coding Sequence, Intron/Exon Organization, and Chromosomal Location of the Gene for the Core I Protein of Human Ubiquinol-Cytochrome c Reductase." J.Biol.Chem. (1993) 268:21113-21119. (GI 1082896).
Kleiber, J. et al., "The general mitochondrial matrix processing protease from rat liver: Structural characterization of the catalytic subunit." Proc.Natl.Acad.Sci.USA (1990) 87:7978-7982.
Paces, V. et al., (GI 294589) GenBank Sequence Database (Accession L12965), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No date provided.
Paces, V. et al., (GI 294588) GenBank Sequence Database (Accession L12965), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No date provided.
Hoffman, G.G. et al., (GI 1082896) GenBank Sequence Database (Accession A48043), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No date provided.
Hoffman, G.G. et al., (GI 349472) GenBank Sequence Database (Accession L16842), National Center for Biotechnology Information National Library of Medicine, Bethesda, Maryland, 20894. No date provided.
Kitada, S., et al., "Molecular cloning of the smaller subunit (P52) or rat liver mitochondrial processing protease," Biochm Biophys Res Commun., 1993, 190(1):289-293.
Kalousek, F., et al., "Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins," Trends Biochem. Sci., (1993) 18(7):249.
Niidome, T., et al., "Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate," J. Biol. Chem., (1994), 269(40):24719-24722.
Kitada, S., et al., "A putative metal-binding site in the beta subunit of rat mitochondrial processing peptidase is essential for its catalytic activity," J. Biochem (Tokyo), (1995), 117(6):1148-1150.
Rawlings, N.D., et al., "Homologues of insulinase, a new superfamily of metalloendopeptidases," Biochem. J., (1991), 275:389-391.

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