Mitigation of photodamage in analytical reactions

Details Mitigation of photodamage in analytical reactions Mitigation of photodamage in analytical reactions

2011-08-09

2011-08-09

Saucier, Sandra (Department: 1653)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S091100, C435S183000, C424S094100, C424S094500

Reexamination Certificate

active

07993895

ABSTRACT:
Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.

REFERENCES:
patent: 4689307 (1987-08-01), Schwartz
patent: 4979824 (1990-12-01), Mathies et al.
patent: 5547839 (1996-08-01), Dower et al.
patent: 5674716 (1997-10-01), Tabor et al.
patent: 5821058 (1998-10-01), Smith et al.
patent: 5866331 (1999-02-01), Singer et al.
patent: 6190685 (2001-02-01), Karita
patent: 6210896 (2001-04-01), Chan
patent: 6296810 (2001-10-01), Ulmer
patent: 6544797 (2003-04-01), Buechler et al.
patent: 6818395 (2004-11-01), Quake et al.
patent: 6869764 (2005-03-01), Williams et al.
patent: 6953659 (2005-10-01), Jacobson et al.
patent: 6982146 (2006-01-01), Schneider et al.
patent: 7033762 (2006-04-01), Nelson et al.
patent: 7033764 (2006-04-01), Korlach et al.
patent: 7052847 (2006-05-01), Korlach et al.
patent: 7056661 (2006-06-01), Korlach et al.
patent: 7056676 (2006-06-01), Korlach et al.
patent: 7064197 (2006-06-01), Rabbani et al.
patent: 2002/0064524 (2002-05-01), Cevc
patent: 2002/0100896 (2002-08-01), Koizumi et al.
patent: 2002/0156037 (2002-10-01), Volkin et al.
patent: 2003/0044781 (2003-03-01), Korlach et al.
patent: 2003/0087259 (2003-05-01), Clancy et al.
patent: 2003/0124576 (2003-07-01), Kumar et al.
patent: 2003/0174992 (2003-09-01), Levene et al.
patent: 2003/0186276 (2003-10-01), Odedra
patent: 2003/0190647 (2003-10-01), Odera
patent: 2003/0194740 (2003-10-01), Williams
patent: 2003/0215862 (2003-11-01), Parce et al.
patent: 2004/0048301 (2004-03-01), Sood et al.
patent: 2004/0170585 (2004-09-01), Berens et al.
patent: 2004/0224319 (2004-11-01), Sood et al.
patent: 2005/0026847 (2005-02-01), Jacobs et al.
patent: 2005/0141843 (2005-06-01), Warden et al.
patent: 2005/0148027 (2005-07-01), Pirrung et al.
patent: 2005/0233399 (2005-10-01), Aebersold et al.
patent: 2005/0271705 (2005-12-01), Hughes et al.
patent: 2006/0229407 (2006-10-01), Vogel et al.
patent: 2008/0299565 (2008-12-01), Schneider et al.
patent: 2009/0202993 (2009-08-01), Lagunavicius et al.
patent: 428000 (1991-05-01), None
patent: 1105529 (2005-09-01), None
patent: 2123303 (1990-05-01), None
patent: WO 91/06678 (1991-05-01), None
patent: WO 96/27025 (1996-09-01), None
patent: WO 99/05315 (1999-02-01), None
patent: WO 00/36152 (2000-06-01), None
patent: WO 01/16375 (2001-03-01), None
Kapanidis et al. J. Chem. Phys. (2002) 117(25): 10953-10964.
M. J. Levene, et al., “Zero-Mode Waveguides for Single-Molecule Analysis at High Concentrations,”Science, 299:682-686 (Jan. 31, 2003).
Debey et al., Israel J. Chem. (1970) 8:115-123.
Dittrich at al., “Photobleaching and stabilization of fluorophores used for single-molecule analysis with one-and two-photon excitation” Appl Phys 13 (2001) 73:829-837.
Giloh, H. et al., “Fluorecence microscopy: reduced photobleaching of rhodamine and fluorescein protein conjugates by n-propyl gallate” Science (1982) 217:1252-1255.
Piston et al. , “Molecular expressions optical microscopy primer: specialized techniques”webpage (2004) http://www.microscopy.fsu.edu/primer/techniques/fluorescence/multiphoton/multiphotonintro.html.
Song, L. et al., “Influence of the triplet excited statea on the photobleaching kinetics of fluorescein in the microscopy” Biophys J (1996) 70(6):5969-2968.
Subramanyam,R. et al., “Protective effect of active oxygen scavengers on protein degradation and photochemical function in photosystem I submembrane fractions during light stress” FEBS J. (2005) 272(4):892-902.
Van Dijk et al., J. Phys. Chem. B (2004) 108:6479-6484.
Derwent Abstract (English) for JP 02123303 downloaded Apr. 20, 2009.
Extended EP Search Report from related case EP06838800.8, dated Jun. 1, 2010.
International Preliminary Report on Patentability from related PCT/US2006/046025, dated Jan. 17, 2008.

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