Mite galectin

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

active

07135552

ABSTRACT:
A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance capable of modifying the galectin, are disclosed. According to the galectin, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as rickettsiosis, filariasis, Q fever, African recurrent fever, or viral encephalitis.

REFERENCES:
patent: WO 03/072609 (2003-09-01), None
Yagi, F. et al. Glycoconjugate Journal 18: 745-749 (2001).
Astigarraga et al. Veterinary Parasitology 60: 133-147 (1995). “A study of the vaccinal value of various extracts of concealed antigens and salivary gland extracts against Ornithodoros erraticus and Ornithodoros moubata”.
C.A. Hill et al, “EST, Amblyomma Americanum”, EMBL-EBI, Oct. 14, 2000, database accession No. BF007251 (XP-002328634).
C.A. Hill et al, “Analysis of the Expressed Genome of the Lone Star Tick, Amblyomma Americanum (Acari: Ixodidae) Using an Expressed Sequence Tag Approach”, Microbial & Comparative Genomics, Nov. 2, 2000, pp. 89-101, vol. No. 5 (XP 009047874).
Kovar V. et al., Isolation and characterization of Dorin M., a lectin from plasma of the soft tick, Ornithodoros moubata Insect. Biochem. Mol. Biol., 2000, 30 (3), pp. 195 to 205.
Grubhoffer L. et al., New Lectins of Invertebrates, Zool. Sci., 1991, 8 (6), pp. 1001 to 1003.

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