Mistletoe extract and method

Details Mistletoe extract and method Mistletoe extract and method

1997-02-05

1998-07-14

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A61K 3578

Patent

active

057800375

ABSTRACT:
A method for making and identifying mistletoe extracts as being of a pharmaceutical grade which is useful in treating AIDS, cancers and other diseases where the immune system is suppressed. The method is based on the discovery of five marker proteins which selectively bind with different sugars. Pharmaceutical grade extracts in accordance with the invention require certain concentration levels of each protein. An additional further requirement is that each protein fraction must meet specific bioactivity levels with respect to preventing malignant cell proliferation. Fingerprint markers with respect to viscotoxins and alkaloids present in the extract are also provided. Methods of treatment using the pharmaceutical grade mistletoe are disclosed.

REFERENCES:
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patent: 3472831 (1969-10-01), Vester
patent: 3475102 (1969-10-01), Vester
patent: 5401502 (1995-03-01), Wunderlich et al.
Gawlik et al., 1992, "Antiproliferative Effect of Mistletoe-Extracts In Melanoma Cell Lines", Anticancer Research 12(6A):1882.
E. Jordan and H. Wagner, "Structure and Properties of Polysaccharides from Viscum album", Oncology 43:(1)8-15, 1986.
Wren, Potter's Cyclopedia, p. 236, 1952.

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