Misoprostol

Details Misoprostol Misoprostol

1996-05-17

1997-11-04

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

556112, 562503, C07C17700

Patent

active

056841779

ABSTRACT:
In a process for making synthetic prostaglandin-type compounds such as misoprostol, organo metallic cuprate complexes capable of reacting with cyclopentenones are prepared by reaction of an alkyl lithium compound with a cuprous halide, followed by reaction of the resulting complex with a vinyl stannane, using an excess of alkyl lithium in the initial reaction and maintaining the excess present during the formation of the organo metallic cuprate complex.

REFERENCES:
patent: 4777275 (1988-10-01), Campbell et al.
patent: 4904820 (1990-02-01), Campbell et al.

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