Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Reexamination Certificate
2007-01-23
2007-01-23
Cole, Monique T. (Department: 1743)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
C530S350000
Reexamination Certificate
active
10161061
ABSTRACT:
A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles as is the case in many body-fluid derived samples.
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Davidson Eugene A
Grosset Anne
Orser Cindy
Areté Associates
Cole Monique T.
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