Misfolded protein sensor method

Details Misfolded protein sensor method Misfolded protein sensor method

2010-03-18

2011-11-22

Mui, Christine T (Department: 1774)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

C436S166000, C436S164000, C530S350000

Reexamination Certificate

active

08062895

ABSTRACT:
A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.

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