Minoxidil analogs as inhibitors of cell proliferation and lysyl

Details Minoxidil analogs as inhibitors of cell proliferation and lysyl Minoxidil analogs as inhibitors of cell proliferation and lysyl

1992-12-11

1994-07-12

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, A61K 31505

Patent

active

053289137

ABSTRACT:
The present invention relates to a method of inhibiting cell proliferation and lysyl hydroxylase expression. The method involves the use of minoxidil derivatives. The inhibitory activity of hydroxy derivatives of minoxidil is such that these compounds can be used as selective antifibrotic agents.

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patent: 5114943 (1992-05-01), Ulrich
Priestley et al., "The metabolism of fibroblasts from normal and fibrotic skin is inhibited by minoxidil in vitro", British Journal of Dermatology (1991) 125:217-221.
Hautala et al., "Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts", Biochem. J. (1992) 283:51-54.
Hughes et al., "Minoxidil-Induced Changes in the Contraction of Collagen Lattices by Human Skin Fibroblasts", Plastic and Reconstructive Surgery, Apr. 1992, vol. 89, No. 4, pp. 722-730.
Murad et al., "Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, Inc., vol. 262, No. 25, Issue of Sep. 5, 1987, pp. 11973-11978.
Murad et al., "Structure-Activity Relationship of Minoxidil Analogs as Inhibitors of Lysyl Hydroxylase in Cultured Fibroblasts", Archives of Biochemistry and Biophysics, vol. 292, No. 1, Jan. 1992, pp. 214-238.
Murad et al., "Structure-Function Relationship for Suppression of Skin Fibroblast Lysyl Hydroxylase Activity by Minoxidil", J. Invest. Dermatol. vol. 90, No. 4 Apr. 1988.

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