Minimum recognition unit of a pem mucin tandem repeat specific m

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...

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424 91, 4241381, 4241521, 4241561, 435 723, 435 79, 5303877, 5303888, 53038885, 5303913, A61K 5100, A61K 39395, G01N 33574, C07K 1600

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058339434

ABSTRACT:
The peptide EPPT (Glu-Pro-Pro-Thr) (SEQ ID NO:1) selectively binds a mucin expressed by epithelial tumors. It may be incorporated into larger molecules, such as peptides consisting of the sequence EPPT and further amino acids to form a peptide, and may be radiolabelled or used to guide toxins, etc. to cells expressing the mucin.

REFERENCES:
McCray, J. & Werner, G. (1989) Meth. Enzymol. 178, 676-692. Production and properties of site-specific antibodies to synthetic peptide antigens related to potential cell surface receptor sites for rhinovirus.
Burchell, J., Taylor-Papadimitriou, J., Boshell, M., Gendler, S. & Duhig, T. (1989) Int. J. Cancer 44, 691-696. A short sequence, within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes.
Price, M.R., Hudecz, F., O'Sullivan, C., Baldwin, R.W., Edwards, P.M. & Tendler, S.J.B. (1990) Mol. Immumol. 27, 795-802. Immunological and structural features of the protein core of human polymorphic epithelial mucin
Price, M.R., Pugh, J.A., Hudecz, F., Griffiths, W., Jacobs, E., Symonds, I.M., Clarke, A.J., Chan, W.C. & Baldwin, R.C. (1990) Br. J Cancer 61, 681-686. C595--a monoclonal antibody against the protein core of human urinary epithelial mucin commonly expressed in breast carcinoma.
Tendler, S.J.B. (1990) Biochem. J. 267, 733-737. Elements of secondary structure in a human epithelial mucin core peptide fragment.
Girling, A., Bartkova, J., Burchell, J., Gendler, S., Gillett, C. & Taylor-Papadimitriou, J. (1989) Int. J. Cancer 43, 1072-1076. A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas.
Xing, P.-X., Tjandra, J.J., Stacker, S.A., Teh, J.G., Thompson, C.H., McLaughlin, P.J. & McKenzie, I.F.C. (1989) Immunol. Cell Biol. 67, 183-195 Monoclonal antibodies reactive with mucin expressed in breast cancer.
Gendler, S., Taylor-Papadimitriou, J., Duhig, T., Rothbard, J. & Burchell, J. (1988) J. Biol. Chem. 263, 12820-12823. A highly immumogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats.
Winter, G. & Milstein, C. (1991) Nature 349, 293-299. Man-made antibodies.
Riechmann, L., Clark, M., Waldmann, H. & Winter, G. (1988) Nature 332, 323-327 Reshaping human antibodies for therapy.
Verheijen, R.H.M., Massuger, L.F.A.G., Kenemans, P., Haisma, H.J. & Epenetos, A.A. (1988) Cancer Rev. 11-12, 145-172. Polymorphic epithelial mucin and CA125-bearing glycoprotein as targets for imaging and therapy with monoclonal antibodies.
McCafferty, J., Griffiths, A.D., Winter, G. & Chiswell, D.J. (1990) Nature 348, 552-554. Phage antibodies: filamentous phage displaying antibody variable domains.
Taub, R., Gould, R.J., Garsky, V.M., Ciccarone, T.M., Hoxie, J., Friedman, P.A. & Shattil, S.J. (1989) J. Biol. Chem. 264, 259265 A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen.
Huse, W.D., Sastry, L., Iverson, S.A., Kang, A.S., Alting-Mees, M., Burton, D.R., Benkovic, S.J. & Lerner, R.A. (1989) Science 246, 1275-1281 Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda.
Williams, G. (1988) Tibtech 6, 36-42. Novel antibody reagents: production and potential.
Tan, L.K. & Morrison, S.L. (1988) Adv. Drug Deliv. Rev. 2, 129-142. Antibody structure and antibody engineering.
Verhoeyen, M., Miltstein, C. & winter, G. (1988) Science 239, 1534-1536 Reshaping human antibodies: rafting an antilysozyme activity.
Williams, W.V., Moss, D.A., Kieber-Emmons, T., Cohen, J.A., Myers, J.N., Weiner, D.B. & Greene, M.I. (1989) Proc. Natl. Acad. Sci. USA 86, 5537-5541 Development of biologically active peptides based on antibody structure.
Harris et al Tibtech 11 :42-44, 1993.
Waldman Science 252: 1657-1662, 1991.
Schlom "Molecular Foundations of Oncology" Broder Ed. Williams & Wilkins pp. 95-134, 1991.
Osband et al (Immunology Today vol. 11 No. 6 pp. 193-195), 1990.

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