Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving glucose or galactose
Patent
1988-04-28
1993-01-12
Moskowitz, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving glucose or galactose
435 4, 435 25, 435 28, 435805, 435808, 435810, 436 24, 436 46, 436 63, 436 95, 436166, 436169, 422 56, 422 57, 422 58, 422 61, 422 681, C12Q 154, C12Q 126, C12Q 128, G01N 3314, G01N 3500, G01N 3348, G01N 2100
Patent
active
051790050
ABSTRACT:
A method for determining the presence of an analyte in a fluid is described along with various components of an apparatus specifically designed to carry out the method. The method involves taking a reflectance reading from one surface of an inert porous matrix impregnated with a reagent that will interact with the analyte to produce a light-absorbing reaction product when the fluid being analyzed is applied to another surface and migrates through the matrix to the surface being read. Reflectance measurements are made at two separate wavelengths in order to eliminate interferences, and a timing circuit is triggered by an initial decrease in reflectance by the wetting of the surface whose reflectance is being measured by the fluid which passes through the inert matrix. Repeatability is insured by a normalization technique performed on the light source before each reading, and an alignment method operated on the reagent strip prior to emplacement on the apparatus. The method and apparatus are particularly suitable for the measurement of glucose levels in blood without requiring separation of red blood cells from serum or plasma.
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Jurik Franklin A.
McGarraugh Geoffery
Phillips Roger
Underwood Raymond D.
Coletti Paul A.
Fleisher Mindy B.
Lifescan Inc.
Moskowitz Margaret
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