Minimally compliant, volume-efficient piston for osmotic...

Details Minimally compliant, volume-efficient piston for osmotic... Minimally compliant, volume-efficient piston for osmotic...

2006-09-26

2006-09-26

Kennedy, Sharon (Department: 3767)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C604S892100

Reexamination Certificate

active

07112335

ABSTRACT:
An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length-to-total-diameter ratio of about 1.1:1 and a core-diameter-to-total-diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.

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