Minimal derivatization of proteins

Details Minimal derivatization of proteins Minimal derivatization of proteins

1988-04-29

1991-10-22

Hollrah, Glennon H.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436547, 436548, 436804, 436819, 436518, 435188, 530387, 530402, 530405, 530408, 424 11, G01N 33566

Patent

active

050595415

ABSTRACT:
There is disclosed a process for minimally derivatizing a targeting protein with a radionuclide such that the predominant species of derivatized targeting protein contains one radionuclide group as a single radiolabeled ligand, and whereby the binding characteristics of the targeting protein are minimally affected. There is further disclosed ligands that can chelate a metal radionuclide or bind a halogen radionuclide while providing a means for separating radiolabeled ligand from unradiolabeled ligand.

REFERENCES:
patent: 4305922 (1981-12-01), Rhodes
patent: 4331647 (1982-05-01), Goldenberg
patent: 4348376 (1982-09-01), Goldenberg
patent: 4361544 (1982-11-01), Goldenberg
patent: 4421735 (1983-12-01), Haber et al.
patent: 4444744 (1984-04-01), Goldenberg
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4460559 (1984-07-01), Goldenberg
patent: 4460561 (1984-07-01), Goldenberg
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4624846 (1986-11-01), Goldenberg
patent: 4668503 (1987-05-01), Hnatowich
patent: 4707352 (1987-11-01), Stavrianpoulos
patent: 4732864 (1988-03-01), Tolman
patent: 4732974 (1988-03-01), Nicolotti et al.
patent: 4741900 (1988-05-01), Alvarez et al.
patent: 4824986 (1989-04-01), Gansow
Chang et al., "Bifunctional Chelating Agents: Linking Radiometals to Biological Molecules," in Applications of Nuclear and Radiochemistry, Chapter 10, pp. 103-114.
Arano et al., "Synthesis and Evaluation of a New Bifunctional Chelating Agent for .sup.99m Tc Labeling Proteins: p-Carboxyethylphenylglyoxal-di(N-methylthio-semicarbazone)," Int. J. Nucl. Med. Biol. 12:425-30 (1986).
Eckelman et al., "Radiolabeling of Antibodies," Cancer Research 40:3036-3042 (1980).
Holland et al., "Studies on Commercially Available .sup.99 Mo/.sup.99m Radionuclide Generators--I. Comparison of Five Analytical Procedures for Determination of Total Technetium in Generator Eluants," App. Radiat. Isot. 37:165-171 (1986).
Holland et al., "Studies on Commercially Available .sup.99 Mo/.sup.99m Tc Radionuclide Generators--II. Operating Characteristic and Behavior of .sup.99 Mo/.sup.99m Tc Generators," Appl. Radiat. Isot. 37:173-180 (1986).

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