Miniaturized cell array methods and apparatus for cell-based scr

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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422 57, 422 60, 422 63, 435 34, 4352878, 4352879, 436518, 436524, 436527, 427466, 427402, 216 2, 216 11, G01N 3353

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061034797

ABSTRACT:
The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellular and subcellular level as well as temporal information about changes in physiological, biochemical and molecular activities. The present invention allows multiple types of cell interactions to be studied simultaneously by combining multicolor luminescence reading, microfluidic delivery, and environmental control of living cells in non-uniform micro-patterned arrays.

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