Mini-proinsulin, its preparation and use

Details Mini-proinsulin, its preparation and use Mini-proinsulin, its preparation and use

2005-04-05

2005-04-05

Saoud, Christine J. (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S069100, C435S069400, C435S243000, C435S254200, C530S303000, C530S305000, C536S023400, C536S023500, C536S023510

Reexamination Certificate

active

06875589

ABSTRACT:
A mini-proinsulin, in which the amino acid Arg bridges the A and the B chain instead of the C chain, shows insulin activity and is suitable for the preparation of pharmaceuticals for the treatment of diabetes mellitus. It can furthermore be converted into an insulin derivative simply using trypsin, the B chain of which is lengthened by Arg. This can be converted into insulin using carboxypeptidase B. Advantageously, however, the mini-proinsulin can also be converted to insulin directly in a one-pot process.

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