Mineralized three-dimensional bone constructs

Details Mineralized three-dimensional bone constructs Mineralized three-dimensional bone constructs

2007-03-29

2011-12-13

Kim, Taeyoon (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of co-culturing cells

C435S291800, C435S325000, C435S347000, C435S377000

Reexamination Certificate

active

08076136

ABSTRACT:
The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.

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