Liquid purification or separation – Processes – Preventing – decreasing – or delaying precipitation,...
Patent
1995-02-07
1998-07-07
McCarthy, Neil
Liquid purification or separation
Processes
Preventing, decreasing, or delaying precipitation,...
210702, C02F 510, C02F 512
Patent
active
057763488
ABSTRACT:
The present invention provides a system for the analysis of mineral precipitate formation, and for the identification of compounds that affect mineral precipitation. The invention also provides methods and compositions for inhibiting formation of mineral precipitates, especially of mineral precipitates including struvite and/or calcium phosphate. Furthermore, the invention provides methods and compositions for the diagnosis and treatment of struvite kidney stones.
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Bagley, "Pharmacologic Treatment of Infection Stones", Urologic Clinics of North America, vol. 14, No. 2, May 1987.
Bennett et al., "Identification of the Calcium-Binding Protein Calgranulin in the Matrix of Struvite Stones", Jour. of Endourology, vol. 9, No. 2, 1994.
Hedelin et al., "The Effects of Fractioned Human Urine of Urease-Induced Crystallisation In Vitro", Urol. Res., vol. 18, pp. 35-38, 1990.
Hess, "Prophylaxis of Infection-Induced Kidney Stone Formation", Urol. Res. vol. 18, pp. S45-S48, 1990.
Selengut et al., "Calgranulin in Matrix Protein", J. Urology, 149;232, 1993.
Selengut, "Studies in Biochemistry: Steriod Synthesis, P-450 Enzymology and Renal Lithogenesis", Ph.D. Dissertion, Massachusetts Institute of Technology Dept. of Chemistry, 1994.
Yamaguchi et al., "Heparan Sulfate in the Stone Matrix and its Inhibitory Effect on Calcium Oxalate Crystallization", Urol. Res. 21:187, 1993.
Asakura Hirotaka
Dretler Stephen P.
Orme-Johnson William H.
Selengut Jeremy D.
Massachusetts Institute of Technology
McCarthy Neil
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