Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1995-03-17
1998-10-06
Cunningham, Thomas M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
530326, 530327, 530328, 530380, 4241851, 514 2, 514 15, C07K 700, C07K 14745, A61K 3808, A61K 3836
Patent
active
058177485
ABSTRACT:
The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 are specifically provided.
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Lyle Vicki A.
Miller Jonathan L.
Braman, Esq. Susan J.
Cunningham Thomas M.
The Research Foundation of State University of New York
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