Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/I

Details Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/I Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/I

1995-11-13

1999-03-02

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530300, 530328, 4241531, C07K 706, A61K 3808, A61K 39395

Patent

active

058771557

ABSTRACT:
The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.

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