Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Reexamination Certificate
2004-12-03
2009-06-09
Szperka, Michael (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
C530S328000, C530S384000, C530S350000, C514S002600
Reexamination Certificate
active
07544774
ABSTRACT:
The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.
REFERENCES:
patent: 5114842 (1992-05-01), Plow et al.
patent: 5122515 (1992-06-01), Smith et al.
patent: 5177188 (1993-01-01), Ginsberg et al.
patent: 5817748 (1998-10-01), Miller et al.
patent: 5877155 (1999-03-01), Miller et al.
patent: 6126939 (2000-10-01), Eisenbach-Schwartz et al.
patent: 7074888 (2006-07-01), Miller et al.
patent: WO 91/09614 (1991-07-01), None
patent: WO 92/09302 (1992-06-01), None
patent: WO 97/18236 (1997-05-01), None
Stryer, L. Biochemistry, 4th edition, W.H. Freeman and Company, 1995, pp. 18-25.
Lubben et al., The EMBO Journal, 1992, 11:805-812.
Balass, M. et al., Proc. Natl. Acad. Sci. USA, 90:10638-10642 (1993).
Califf, R.M. et al., New England Journal of Medicine, 330(14):956-961 (1994).
Christian, R.B. et al., J. Mol. Biol., 227:711-718 (1992).
Collen, D. et al., Thrombosis and Haemostasis, 71(1):95-102 (1994).
Coller, B.S., Annu. Rev. Med., 43:171-180 (1992).
Cwirla, S.E. et al., Proc. Natl. Acad. Sci. USA, 87:6378-6382 (1990).
Ganderton, R.H. et al., Biochem. J., 288:195-205 (1992).
Hobart, M.J. et al., Proc. R. Soc. London. B, 252:157-162 (1993).
Jennings, L.K. et al., Abstract #278, Blood, 84:72a (1994).
Joyce, G.F., Current Opinion in Structural Biology, 4:331-336 (1994).
LaRocca, D. et al., Hybridoma, 11:191-201 (1992).
Lenstra, J.A. et al., J. Immunol. Methods, 152:149-157 (1992).
Mayo, K.H., Trends in Biotechnology, 18:212-217 (2000).
Miller, J.L. et al., Br. J. Haemotol., 74:313-319 (1990).
Miller, J.L. et al., Arteriosclerosis and Thrombosis, 11(5):1231-1236 (1991).
Mousa, S.A. et al., Circulation, 89(1):3-12 (1994).
Otey, C.A. et al., The Journal of Biological Chemistry, 268(28):21193-21197 (1993).
Pearson, W.R., Methods in Enzymology, 183:63-98 (1990).
Pearson, W.R. and Lipman, D.J., Proc. Natl. Acad. Sci. USA, 85:2444-2448 (1988).
Phillips, D.R. et al., Cell, 65:359-362 (1991).
Rote, W.E. et al., Journal of Cardiovascular Pharmacology, 23:681-689 (1994).
Ruan et al., Blood, 69(2):570-577 (1987).
Scott, J.K., Trends in Biochem. Sci., 17:241-245 (1992).
Scott, J.K. and Smith, G.P., Science, 249:386-390 (1990).
Smith, G.P. and Scott, J.K., Methods in Enzymology, 217:228-257 (1993).
South, V. et al., Thrombosis and Haemostasis, 73:144-150 (1995).
Turner, N.A. et al., Abstract #967, Blood, 84:72a (1994).
Ward et al., Leucozyte Typing V: White Cell Differ. Antigens, Proc. Int. Workshop Conf., 5th vol. 2, pp. 1336-1337 Oxford (1995).
Lyle Vicki A.
Miller Jonathan L.
Rogalskyj, Esq. Peter
Szperka Michael
The Research Foundation of State University of New York
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