Mimetics and inhibitors of the interaction between Vpr (HIV...

Details Mimetics and inhibitors of the interaction between Vpr (HIV... Mimetics and inhibitors of the interaction between Vpr (HIV...

2006-06-06

2006-06-06

Park, Hankyel T. (Department: 1648)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S005000, C435S006120, C435S069100, C435S339100, C530S388350

Reexamination Certificate

active

07056735

ABSTRACT:
The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.

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