Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-04-24
2007-04-24
Borin, Michael (Department: 1631)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S330000
Reexamination Certificate
active
10659233
ABSTRACT:
Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acid residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.
REFERENCES:
Database Caplus, DN 130:1686. Nachman, R. J.; Moyna, G.; Williams, H. J.; Garside, C.; Tobe, S. S. Advances in Comparative Endocrinology, Proceedings of the International Congress of Comparative Endocrinology, 13th, Yokohama, Nov. 16-21, 1997, vol. 2, 1353-1359. Editor(s): Kawashima, S. et al. Publisher: Monduzzi Editore, Bologna, Italy.
Garside Christopher S.
Nachman Ronald J.
Teal Peter E. A.
Tobe Stephen S.
Borin Michael
Deck Randall E.
Fado John D.
Shaw Lesley
The United States of America as represented by the Secretary of
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