Milled naproxen with hydroxypropyl cellulose as a dispersion sta

Details Milled naproxen with hydroxypropyl cellulose as a dispersion sta Milled naproxen with hydroxypropyl cellulose as a dispersion sta

1995-02-10

1997-01-07

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424493, 424499, 514781, 514951, A61K 918, A61K 914

Patent

active

055914560

ABSTRACT:
Dispersible particles consisting essentially of crystalline NSAID having hydroxypropyl cellulose adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm. Pharmaceutical compositions containing the particles exhibit unexpectedly reduced gastric irritation following oral administration and/or hastened onset of action.

REFERENCES:
patent: 4826689 (1989-05-01), Violanto et al.
patent: 5145684 (1992-09-01), Liversidge et al.
Cioli, et al., "Toxicological and Applied Pharmacology", vol. 50, 1979, pp. 283-289.
Price et al, "Drugs", 40 (Suppl. 5); 1-11, 1990.

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