Mikanolide derivatives, their preparation and therapeutic uses

Details Mikanolide derivatives, their preparation and therapeutic uses Mikanolide derivatives, their preparation and therapeutic uses

2005-05-03

2005-05-03

Dentz, Bernard I. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S321000, C514S409000, C514S443000, C514S444000, C514S468000, C544S148000, C546S197000, C548S409000, C548S494000, C549S057000, C549S060000, C549S267000, C549S297000, C549S298000

Reexamination Certificate

active

06887869

ABSTRACT:
The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)1and (I)2, wherein: R1represents H, SR4or NR4R5; R2represents SR6or NR6R7; R3represents OH, O(CO)R14, OSiR15R16R17, O(CO)OR18or O(CO)NHR18, each of the radicals R4, R6, R15, R16and R17representing independently (in particular) an alkyl radical, the radicals R5and R7representing (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals R14and R18representing independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)2, then R1does not represent a hydrogen atom

REFERENCES:
patent: 2801792 (2001-06-01), None
Kupchan et al, “The . . .Elephantopus elatus”, Journal of the American Chemical Society, vol. 88, No. 15, 1966 pp. 3674-3676.
Facey et al, Investigation . . . Pharmacology, Journal of Pharmacy and Pharmacology, London, GB, vol. 51, 1999, pp. 1455-1460.

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