MIF-inhibitors

Details MIF-inhibitors MIF-inhibitors

2005-10-19

2008-05-27

Habte, Kahsay T (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S090000

Reexamination Certificate

active

07378416

ABSTRACT:
3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C3-8)cycloalkyl, (C1-4)alkyl(C3-8)cycloalkyl, (C6-18)aryl or (C6-18)aryl(C1-4)alkyl and their use as pharmaceuticals.

REFERENCES:
C. Cimarelli: “A facile synthesis of 3,4-dialkyl-3, 4-2H-1, 3-benzoxazin-2-ones and naphthoxazin-2ones and their reactions with organolithium and grignard reagents—prepraration of N-′1-(2′-hydroxyphenyl) alkyl amides”, Canadian Journal of Chemistry, vol. 82, No. 8, pp. 1314-1321, (2004).
O. Masaya et al., “Coumarain and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitors of macrophage migration inhibitory factor: discovery and x-ray crystallography”, Journal Med. Chem, vol. 44, pp. 540-547, (2001).

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