Mid-life vaccine and methods for boosting anti-mycobacterial...

Details Mid-life vaccine and methods for boosting anti-mycobacterial... Mid-life vaccine and methods for boosting anti-mycobacterial...

2007-10-30

2007-10-30

Swartz, Rodney P (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S009100, C424S009200, C424S184100, C424S185100, C424S190100, C424S234100, C424S278100, C435S243000, C435S253100, C530S300000, C530S350000

Reexamination Certificate

active

10332512

ABSTRACT:
Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective immunity has waned comprise one or more purified immunogenic proteins fromMycobacterium tuberculosisfrom a group of 30 proteins that stimulate T cell immunity and interferon-γ secretion. A preferred protein is Ag85A, the secreted product (SEQ ID NO:31) of the Rv3084c gene. Also disclosed are methods for boosting immunity in such BCG-vaccinated subjects comprising administering an effective amount of the above vaccine composition.

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