Microwave-assisted peptide synthesis

Details Microwave-assisted peptide synthesis Microwave-assisted peptide synthesis

2011-03-08

2011-03-08

Cordero Garcia, Marcela M (Department: 1654)

Electric heating

Microwave heating

With diverse device

C530S333000

Reexamination Certificate

active

07902488

ABSTRACT:
An instrument and associated method are disclosed for the accelerated synthesis of peptides by the solid phase method. The instrument includes a microwave cavity, a microwave source in communication with the cavity, a column in the cavity formed of a material that is transparent to microwave radiation, a solid phase peptide support resin in the column, respective filters for maintaining the solid phase support resin in the column, a first passageway for adding starting compositions to the column, a second passageway for removing compositions from the column, and a third passageway for circulating compositions from the column into the third passageway and back to the column.

REFERENCES:
patent: 3581190 (1971-05-01), Brown
patent: 3647390 (1972-03-01), Kubodera et al.
patent: 3926556 (1975-12-01), Boucher
patent: 4192798 (1980-03-01), Verlander et al.
patent: 4696981 (1987-09-01), Harada et al.
patent: 4746490 (1988-05-01), Saneii
patent: 5288464 (1994-02-01), Nokihara
patent: 5382414 (1995-01-01), Lautenschlager
patent: 5830417 (1998-11-01), Kingston
patent: 6028172 (2000-02-01), Stepaniuk et al.
patent: 6120741 (2000-09-01), Jacquault et al.
patent: 6171555 (2001-01-01), Cargill et al.
patent: 6288379 (2001-09-01), Greene et al.
patent: 6320025 (2001-11-01), Slavazza et al.
patent: 6326090 (2001-12-01), Schultz et al.
patent: 6486455 (2002-11-01), Merabet
patent: 6744024 (2004-06-01), Hayes et al.
patent: 6858434 (2005-02-01), Williams
patent: 6867400 (2005-03-01), Collins et al.
patent: 6917023 (2005-07-01), Hayes et al.
patent: 2002/0117498 (2002-08-01), Jennings
patent: 2003/0082633 (2003-05-01), Martin et al.
patent: 2003/0089706 (2003-05-01), Jennings
patent: 2003/0199099 (2003-10-01), King et al.
patent: 2004/0020923 (2004-02-01), Collins et al.
patent: 2006/0025567 (2006-02-01), Collins et al.
patent: 2006/0025568 (2006-02-01), Collins et al.
patent: 2006/0025569 (2006-02-01), Collins et al.
patent: 2007/0090104 (2007-04-01), Collins et al.
patent: 2007/0270573 (2007-11-01), Collins
patent: 0 541 340 (1993-05-01), None
patent: 1 491 552 (2004-12-01), None
patent: 1 533 025 (2005-05-01), None
patent: 2004/002617 (2010-02-01), None
Bolton et al. Further development of the double cavity microwave pulse compression source and laser-induced plasma switching. Plasma Science, 1990. IEEE Conference Record. p. 153.
European Search Report of counterpart foreign application No. EP 05 10 1287; mailed Nov. 21, 2007; 3 pages.
Ferguson, Doug, “Focused Microwave instrumentation from CED Corporation,” Molecular Diversity 2003, vol. 7 Nr. 2-4, pp. 281-286.
Park W K et al, “New Reaction Vessel for Solid-Phase Peptide Synthesis,” Canadian Journal of Biochemistry, National Research Council of Canada, Ottawa, vol. 50, No. 7, Jan. 1972, pp. 755-757.
Caddick S, “Microwave Assisted Organic Reactions,”Tetrahedron 1985, United Kingdom, vol. 51, No. 38, 1995; pp. 10403-10432.
Hilpert et al., “Anti-c0myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose,” Protein Engineering, Oct. 2001, vol. 14, No. 10, pp. 803-806.
Frank, “The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports-principles and applications,” 2002, Journal of immunological Methods. vol. 267, pp. 13-26.
Kramer et al., “Combinatorial Cellulose-Bound Peptide Libraries: Screening Tools for the Identification of Peptides that bind Ligands with Predefined Specificity,” Methods: A companion to Methods in Enzymology. 1994, vol. 6, pp. 388-395.
Answers.com: vessel. http://www.answers.com/vessel accessed online Mar. 13, 2007, 2 pages.
http://web.archive.org/web/20020514031700/www.sigma-genosys.com/peptide—faq.asp accessed online Nov. 9, 2007.
Hui-Ming Yu et al., Enhanced Coupling Efficiency in Solid-Phase Peptide Synthesis by Microwave Irradiation, The Journal of Organic Chemistry, Aug. 28, 1992, pp. 4781-4785, vol. 57, No. 18,American Chemical Society1992.
Mate Erdely et al., Rapid Microwave-Assisted Solid Phase Peptide Synthesis; Synthesis 2002, Aug. 22, 2002, pp. 1592-1596, No. 11.
Shui-Tein Chen et al., The Studies of Microwave Effects on the Chemical Reactions, Journal of the Chinese Chemical Society, 1997, pp. 169-182, vol. 44, No. 3.
Shui-Tein Chen et al., Enhancement of Chemical Reactions by Microwave Irradiation; Journal of the Chinese Chemical Society, 1991, pp. 85-91, vol. 38, No. 1; Only 1 page Abstract enclosed.
Hernando J. Olivos et al., Microwave-Assisted Solid-Phase Synthesis of Peptoids, Organic Letters, 2002, pp. 4057-4059, vol. 4, No. 23, 2002 American Chemical Society.
N.S. Rao et al., Microwave Assisted High Yielding Preparation of N-Protected 2-Deoxyribonucleosides Useful for Oligonucleotides Synthesis, Necleosides, Nucleotides & Nucleic Acids, 2002, pp. 393-400, vol. 21 (4&5), Marcel Dekker, Inc., New York.
Claire M. Coleman et al., Microwave Parallel Library Generation: Comparison of a Conventional-and Microwave-Generated Substituted 4(5)-Sulfanyl-1H-imidazole Library, J. Comb. Chem. 2002, pp. 87-93 vol. 4, American Chemical Society.
Fluorous Technology in Discovery Applications, Fluorous Technologies, Inc., 2002-2003, http://fluorous.com/scavenging.html, 3 pages.
Louis Carpino, Prinicipal Research Interests, Department of Chemistry—Faculty Research Areas—Louis Carpino, University of Massachuestts, http://www.chem.umass.edu/Carpino/carpino.html 2 pages.
Chemical Synthesis of Peptides, KVL, http://www.kemi.kvl.dk/˜prh/html/research.htm, 9 pages.
Kung-Tsung Wang et al., Enhancement of Coupling Reaction in Peptide Synthesis by Microwave Irradiation, 12 pages.
Fernando Albericio et al., Coupling Reagents and Activation, Methods Enzymol, 1997; 289: 104-126.
Vincenzo Santagada et al., Microwave-Enhanced Solution Coupling of the Alpha, Alpha-dialkyl Amino Acid, Aib, Tetrahedron Letters, vol. 42, No. 31, Jul. 30, 2001, pp. 5171-5173, XP002299120.
M.C. Daga et al., Rapid Microwave-Assisted Deprotection of N-Cbz and N-Bn Derivatives, Tetrahedron Letters, Jul. 30, 2001, United Kingdom, vol. 42, No. 31, pp. 5191-5194, XP0102299121.
J. M. Collins et al., Novel Method for Enhanced Solid Phase Peptide Synthesis Using Microwave Energy, Biopolymers, vol. 71, No. 3, 2003, p. 361, XP002299122.
Andrea Porcheddu et al., A New, Rapid General Procedure for the Synthesis of Organic Molecules Supported on Methoxy-Polyethylene Glycol (MeOPEG) under Microwave Irradiation Conditions, Eur. J. Org. Chem. 2003, pp. 907-912.
Alexander Stadler et al., High speed Couplings and Cleavages in Microwave-Heated, Solid-Phase Reactions at High Temperatures, Eur. J. Org. Chem. 2001, pp. 919-925.
Bruce Merrifield, Concept and Early Development of Solid-phase Peptide Synthesis, Methods Enzymol, 1997; 289: pp. 3-13.
Overview of Peptide Synethsis. Anaspec. Accessed online Feb. 15, 2006 at http://www.anaspec.com/html/peptide—notes.html, pp. 1-11.
Kappe, Speeding Up Solid-Phase Chemistry by Microwave Irradiation. A Tool for High-Throughput Synthesis. American Laboratory, 2001, vol. 33, No. 10, pp. 13-16, 18-19.
Murray et al., Efficient Synthesis of a B-Peptide Combinatorial Library with Microwave-Irradiation. JACS. 2005, vol. 127, pp. 13271-13280.
Al-Obeidi, et al., apid Microwave-Assisted Solid-phase Synthesis (MASS): Parallel and Combinatorial Chemical Library Synthesis. Mini Reviews in Medicinal Chemistry. 2003, vol. 3, pp. 449-460.
Lew et al. Increasing Rates of Reaction: Microwave-Assited Organic Synthesis for Combinatorial Chemistry. J. Comb Chem. Mar./Apr. 2002, vol. 4, No. 2, pp. 95-105.
Lange et al. Recent Advances in Microwave-Assisted Combinatorial Synthesis and Lilbrary Generation. Combinatorial Chemistry and High Throughput Screening. 2005, vol. 8, pp. 595-606.
Scharn et al. Spatially Addressed Synthesis of Amino- and Amino-Oxy-Substituted 1,3,5-Triazine. Arrays on Polymeric Membranes. J. Comb Chem. 2000., vol. 2, pp. 361-369.
Scharn et al. Sequential Nucleophilic Substitution on Halogenated Triazines, Pyrimidines, and Purines: A Novel Approach to

Affiliated with

Also associated with

Rating

Microwave-assisted peptide synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microwave-assisted peptide synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microwave-assisted peptide synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2780776