Microtetraspora strain for preparation of indolopyrrolocarbazole

Details Microtetraspora strain for preparation of indolopyrrolocarbazole Microtetraspora strain for preparation of indolopyrrolocarbazole

1993-12-14

1995-08-01

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

439119, C12N 120

Patent

active

054379962

ABSTRACT:
The resultant compounds of the formula (I) have an excellent antitumor activity.
A process for preparation of a compound represented by the formula ##STR1## wherein X.sup.1 and X.sup.2 each independently represent hydrogen atom, halogen atom, amino group, mono- or di-lower alkylamino group, hydroxyl group, lower alkoxy group, aralkoxy group, carboxyl group, lower alkoxycarbonyl group, lower alkanoyloxy group or lower alkyl group, and

REFERENCES:
patent: 4320199 (1982-03-01), Tomita
Tomita et al., J of Antibiot., vol. 44, 1991 pp. 940-948.
Kroppenstedt et al., In, "The Prokaryotes", ed. Balows et al, 1992 pp. 1085-1106.
Patent Abstract of Japan, JP-A 3-20277/1991, Banyu Pharmaceutical Co. Ltd.
Kojiri et al., "A New Antitumor Substance, BE-13793C, Produced by a Streptomycete", 44 Journal of Antibodies No. 7, Jul. 1991, pp. 723-728.
Hughes, et al., "Synthesis of the Indolo[2,3-a]carbazole Natural Products Staurosporinone and Arcyriaflavin B", J. Chemical Society Perkin Transactions, (1990), pp. 2475-2480.
Reynolds, et al., "The Preparation of .alpha.-and .beta.-Geniobiose Octaacetates", 60 Journal of the American Chemical Society, Oct. 1988, pp. 2559-2561.

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