Microsporidian polar tube proteins, nucleic acids coding for...

Details Microsporidian polar tube proteins, nucleic acids coding for... Microsporidian polar tube proteins, nucleic acids coding for...

2005-05-10

2005-05-10

Navarro, Mark (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C424S185100, C424S191100, C424S265100, C424S266100, C530S350000

Reexamination Certificate

active

06890536

ABSTRACT:
This invention discloses purified complete microsporidian polar tube proteins and the proteins, the amino acid sequences of which are represented in the attached sequence listings as SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 4, SEQ ID No: 5. The invention discloses the genes coding these proteins and their use in the fields of diagnosis.

REFERENCES:
patent: WO 9802745 (1998-01-01), None
Plotkin et al (VaccinesW.B. Saunders Co. Philadelphia p. 571), 1988.*
First Complete Amino Acid Sequence of a Polar Tube Protein in a Microsporidian Species, Encephalitozoon Cuniculi, Frédéric Delbac et al., The Journal of Eukaryotic Microbiology, vol. 44, No. 6, 1997, p. 77S.
Immunocytochemical Identifiation of Spore Proteins in Two Microsporidia, with Emphasis on Extrusion Apparatus, F. Delbac et al., Journal of Eukaryotic Microbiology, vol. 45, No. 2, (Apr. 1998), pp. 224-231.
Identification of Sporal Proteins in two Microsporidian Species: an Immunoblotting and Immunocytochemical Study, F. Delbac et al., The Journal of Eukaryotic Microbiology, vol. 43, No. 5, 1996, p. 101S.
Identification of a Microsporidian Polar Tube Protein Reactive Monoclonal Antibody, Elaine M. Keohane et al., The Journal of Eukaryotic Microbiology, vol. 43, No. 1, 1996, pp. 26-31.
Detection of Microsporidia Spore-Specific Antigens by Monoclonal Antibodies, H.D. Luján et al., Hybridoma, vol. 17, No. 3, (Jun. 1998), pp. 237-243.
Utility of Microsporidian rRNA in Diagnosis and Phylogeny: a Review, L.M. Weiss et al., Folia Parasitologica, vol. 41, 1994, pp. 81-90.
Direct Amplification and Species Determination of Microsporidian DNA From Stool Specimens, S. Katzwinkel-Wladarsch et al., Tropical Medicine and International Health, vol. 1, No. 3, (Jun. 1, 1996), pp. 373-378.
Mapping of Repetitive and Non-Repetitive DNA Probes to Chromosomes of the Microsporidian Encephalitozoon cuniculi, Corinne Biderre et al., GENE: An International Journal on Genes and Genomes, vol. 191, No. 1, (May 20, 1997), pp. 39-45.
The Molecular Characterization of the Major Polar Tube Protein Gene from Encephalitozzon Hellem, a Microsporidian Parasite of Humans, Elaine M. Keohane et al., Molecular and Biochemical Parasitology, vol. 94, (Aug. 1998), pp. 227-236.
On Proteins of the Microsporidian Invasive Apparatus: Complete Sequence of a Polar Tube Protein of Encephalitozoon cuniculi, Frédéric Delbac et al., Molecular Microbiology, vol. 29, No. 3, (Aug. 1998), pp. 825-834.

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