Microspheres, process for their preparation and their use

Details Microspheres, process for their preparation and their use Microspheres, process for their preparation and their use

1995-05-31

2000-09-19

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424499, 424500, 424501, 424502, 261 41, 261 43, A61K 916

Patent

active

061208051

ABSTRACT:
Biocompatible microspheres containing one or more active principals, a biodegradable and biocompatible polymer and a surface-active agent which is also biodegradable and biocompatible, contain less than 10 ppm of heavy metals. These microspheres are prepared by providing a solution of the polymer and of the active principal in a water-immiscible solvent which is more volatile than water and mixing with an aqueous solution of the surface-active agent, followed by evaporation of the solvent.

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patent: 5108759 (1992-04-01), Ramey
patent: 5160745 (1992-11-01), De Luca et al.
patent: 5302400 (1994-04-01), Sipos
Tabata in J. of Biomedical Materials Res. 22 p. 837 (1988).

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