Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-04-28
1998-10-13
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
514952, 428402, 424 95, 562455, 562568, A61K 916, A61K 4712, C07C22900
Patent
active
058208810
ABSTRACT:
Diamide-dicarboxylic acid microspheres are provided. The diamide-dicarboxylic acids may be combined with active agent(s). The resultant composition may be in microsphere form. Also disclosed are methods for administering the microsphere and/or composition that includes the active agent. The microsphere, with or without active agent, may be prepared by (A) solubilizing, in a solvent, at least one diamide-dicarboxylic acid, to yield a first solution; and (B) contacting the first solution with a precipitator solution in which the diamide-carboxylic acid is insoluble and optionally with an active agent.
REFERENCES:
patent: Re24899 (1960-11-01), Green
patent: 2671451 (1954-03-01), Bolger
patent: 2862918 (1958-12-01), Meyer et al.
patent: 2868740 (1959-01-01), Luce
patent: 2971916 (1961-02-01), Schleicher et al.
patent: 3016308 (1962-01-01), Macaulay
patent: 3052655 (1962-09-01), Fox et al.
patent: 3057344 (1962-10-01), Abella et al.
patent: 3076790 (1963-02-01), Fox et al.
patent: 3170802 (1965-02-01), Fukushima
patent: 3190837 (1965-06-01), Brynko et al.
patent: 3474777 (1969-10-01), Figge et al.
patent: 3491093 (1970-01-01), Pachter et al.
patent: 3565559 (1971-02-01), Sato
patent: 3567650 (1971-03-01), Bakan
patent: 3574832 (1971-04-01), Engel et al.
patent: 3576758 (1971-04-01), Emrick
patent: 3725113 (1973-04-01), Chang
patent: 3748277 (1973-07-01), Wagner
patent: 3794561 (1974-02-01), Matsukawa et al.
patent: 3795739 (1974-03-01), Birkmayer et al.
patent: 3822348 (1974-07-01), Higashi et al.
patent: 3849550 (1974-11-01), Teitelbaum
patent: 3937668 (1976-02-01), Zolle
patent: 3939253 (1976-02-01), Bodor et al.
patent: 3956172 (1976-05-01), Saeki et al.
patent: 3962416 (1976-06-01), Katzen
patent: 3976773 (1976-08-01), Curran
patent: 4035507 (1977-07-01), Bodor et al.
patent: 4048268 (1977-09-01), Ludwig
patent: 4061466 (1977-12-01), Sjoholm et al.
patent: 4117801 (1978-10-01), Dannelly et al.
patent: 4147767 (1979-04-01), Yapel
patent: 4183849 (1980-01-01), Hansen
patent: 4199561 (1980-04-01), Roth et al.
patent: 4217370 (1980-08-01), Rawlings et al.
patent: 4239635 (1980-12-01), Rieder
patent: 4272506 (1981-06-01), Schwarzberg
patent: 4289759 (1981-09-01), Heavner et al.
patent: 4345588 (1982-08-01), Widder et al.
patent: 4348384 (1982-09-01), Horikoshi et al.
patent: 4351337 (1982-09-01), Sidman
patent: 4352883 (1982-10-01), Lim
patent: 4357259 (1982-11-01), Senyei et al.
patent: 4388304 (1983-06-01), Nyeki et al.
patent: 4393192 (1983-07-01), Curatolo et al.
patent: 4402856 (1983-09-01), Schnoring et al.
patent: 4405598 (1983-09-01), Brown
patent: 4442090 (1984-04-01), Kakeya et al.
patent: 4446138 (1984-05-01), Pack
patent: 4450150 (1984-05-01), Sidman
patent: 4460563 (1984-07-01), Calanchi
patent: 4462839 (1984-07-01), McGinley et al.
patent: 4462991 (1984-07-01), Higuchi et al.
patent: 4473620 (1984-09-01), Wu et al.
patent: 4483807 (1984-11-01), Asano
patent: 4492684 (1985-01-01), Goosen et al.
patent: 4518433 (1985-05-01), McGinley et al.
patent: 4590265 (1986-05-01), Bogan et al.
patent: 4608278 (1986-08-01), Frank
patent: 4613500 (1986-09-01), Suzuki et al.
patent: 4647455 (1987-03-01), De Bold
patent: 4666641 (1987-05-01), Fickat et al.
patent: 4671954 (1987-06-01), Goldberg
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4703042 (1987-10-01), Bodor
patent: 4708952 (1987-11-01), Salatinjants
patent: 4745161 (1988-05-01), Saudek et al.
patent: 4753804 (1988-06-01), Iaccheri et al.
patent: 4757007 (1988-07-01), Satoh
patent: 4757024 (1988-07-01), Roper
patent: 4757066 (1988-07-01), Shiokari et al.
patent: 4766012 (1988-08-01), Valenti
patent: 4774320 (1988-09-01), Tagliabue et al.
patent: 4789734 (1988-12-01), Pierschbacher
patent: 4835312 (1989-05-01), Itoh et al.
patent: 4837381 (1989-06-01), Steber et al.
patent: 4844904 (1989-07-01), Hamaguchi et al.
patent: 4873087 (1989-10-01), Morishita et al.
patent: 4886663 (1989-12-01), Houghten
patent: 4895725 (1990-01-01), Kantor et al.
patent: 4897444 (1990-01-01), Brynes et al.
patent: 4900730 (1990-02-01), Miyauchi
patent: 4919939 (1990-04-01), Baker
patent: 4925673 (1990-05-01), Steiner
patent: 4963364 (1990-10-01), Fox et al.
patent: 4976968 (1990-12-01), Steiner
patent: 4983402 (1991-01-01), Steiner
patent: 4996292 (1991-02-01), Fox et al.
patent: 5023374 (1991-06-01), Simon
patent: 5039481 (1991-08-01), Pacifici et al.
patent: 5055300 (1991-10-01), Gupta
patent: 5066487 (1991-11-01), Morelle et al.
patent: 5067961 (1991-11-01), Kelman et al.
patent: 5069936 (1991-12-01), Yen
patent: 5077278 (1991-12-01), Hafner et al.
patent: 5100669 (1992-03-01), Hyon et al.
patent: 5100918 (1992-03-01), Sunshine et al.
patent: 5122367 (1992-06-01), Ron et al.
patent: 5126147 (1992-06-01), Silvestri et al.
patent: 5137892 (1992-08-01), Chu et al.
patent: 5186947 (1993-02-01), Goettsche et al.
patent: 5204099 (1993-04-01), Barbier et al.
patent: 5206384 (1993-04-01), Shibahara et al.
patent: 5216124 (1993-06-01), Hansen, Jr. et al.
patent: 5244653 (1993-09-01), Berke et al.
patent: 5250236 (1993-10-01), Gasco
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5278148 (1994-01-01), Branca et al.
patent: 5328992 (1994-07-01), Peter et al.
patent: 5352461 (1994-10-01), Feldstein et al.
patent: 5384133 (1995-01-01), Boyes et al.
patent: 5389379 (1995-02-01), Dirix et al.
patent: 5418010 (1995-05-01), Janda et al.
Airaudo, C.B. et al. (1987) Journal of Food Science, vol. 52(6), pp. 1750-1752.
Andihi, S. et al. (1975) Origins of Life, vol. 6, pp. 147-153.
Brooke, S. 1 et al. (1977) BioSystems, vol. 9, pp. 1-22.
Chen et al. (1975) "Evidence for Hemiacetal Formation", Biochemistry, vol. 18, No. 5, pp. 921-925.
Davis et al. (1983) "Leucinal Inhibits . . . ", Pharmacology Biochemistry Behavior, vol. 19, pp. 791-794.
Dose, K. (1974) Origins of Life, vol. 5, pp. 239-252.
Fasman et al. (1964) Biochemistry, vol. 3, No. 11, pp. 1665-1674.
Fox, S.W. et al. (1976) BioSystems, vol. 8, pp. 40-44.
Fox, S.W. et al., Molecular Evolution and the Origin of Life, Maxel Decker, New York (1977).
Fox, S.W. et al. (1968) Biochim. Biophys. Acta, vol. 160, pp. 246-249.
Fox, S.W. (1976) Origins of Life, vol. 7, pp. 49-68.
Fox, S.W. (1980) Naturwissenschaften, vol. 67, pp. 378-383.
Fox, S.W. et al. (1960) Archives of Biochemistry and Biophysics, vol. 86, pp. 281-285.
Fox, S.W. et al. (1974) Origins of Life, vol. 5, pp. 227-237.
Fox, S.W. (1984) Origins of Life, vol. 14, pp. 485-488.
Gol'dovskii, A.M. (1978) Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, vol. 14(6), pp. 437-439.
Gurrieri, S. et al. (1973) Thermochimica Acta, vol. 7, pp. 231-239.
Harada, K. et al. (1979) BioSystems, vol. 11, pp. 47-53.
Harada et al., (1960) Archives of Biochemistry and Biophysics, vol. 86, pp. 274-280.
Hare (1970) Etude Cenetique De La Polycondensation Thermique D'.sub.X -Amino Acides, vol. 45, pp. 330-339.
Heinrich, M.R. et al. (1969) Archives of Biochemistry and Biophysics, vol. 130, pp. 441-448.
Heinz, B. et al. (1981) BioSystems, vol. 14, pp. 33-40.
Hennon, G. et al. (1975) Biochimie, vol. 57, pp. 1395-1396.
Hsu, L.L. et al. (1976) BioSystems, vol. 8, pp. 89-101.
Hsu, L.L. et al. (1971) Currents in Modern Biology, vol. 4, pp. 12-25.
Ishima, Y. et al. (1981), BioSystems, vol. 14, pp. 243-251.
Jackson et al. (1991) "Pharmacological . . . ", J. Pharm. & Exp. Thera., vol. 261, No. 1, pp. 546-552.
Jungck, J.R. et al. (1973) Naturwissenschaften, vol. 60, pp. 425-427.
Kokufuta, E. et al. (1984) BioSystems, vol. 16, pp. 175-181.
Lacey, Jr., J.C. et al. (1979) BioSystems, vol. 11, pp. 9-17.
Lacey, Jr., J.C. et al. (1979) BioSystems, vol. 11, pp. 1-7.
Martinez Luque-Romero, M. et al. (1986) BioSystems, vol. 19, pp. 267-272.
Masinovsky, Z. et al. (1989) BioSystems, vol. 22, pp. 305-310.
Matsuno, K. (1982) BioSystems, vol. 15, pp. 1-11.
Matsuno, K. (1984) BioSystems, vol. 17, pp. 11-14.
Matsuno, K. (1981) BioSystems, vol. 14, pp. 163-170.
McAlhaney, W.W. et al. (1976) BioSystems, vol. 8, pp. 45-50.
Melius, P. et al. (1987) BioSystems, vol. 20, pp. 213-217.
Melius, P. et al. (1975) Bioorganic Chemistry, vol. 4, pp. 385-391.
Melius, P. (1979) BioSystems, vol. 11, pp. 125-132.
Miquel,
Emisphere Technologies Inc.
Webman Edward J.
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