Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2006-02-21
2006-02-21
Hartley, Michael (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S490000, C424S497000, C424S501000, C424S001290
Reexamination Certificate
active
07001616
ABSTRACT:
The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitive microspheres to a patient in need of anticancer therapy. The pH-sensitive microspheres have a swelling transition with the pH range found in or near tumor tissue. When the microspheres swell, the loaded drug is released into the microenvironment of the tumor tissue. The subject invention also pertains to novel microspheres useful in the methods of the invention. The microspheres are capable of effectively releasing a loaded substance at a predetermined pH. The subject invention also concerns novel methods for synthesizing the microspheres of the present invention.
REFERENCES:
patent: 4321117 (1982-03-01), Kaetsu et al.
patent: 4438239 (1984-03-01), Rembaum et al.
patent: 4536387 (1985-08-01), Sakamoto et al.
patent: 4584368 (1986-04-01), Rubin
patent: 4642111 (1987-02-01), Sakamoto et al.
patent: 4997913 (1991-03-01), Hellstrom et al.
patent: 5122368 (1992-06-01), Greenfield et al.
patent: 5286495 (1994-02-01), Batich et al.
patent: 5302369 (1994-04-01), Day et al.
patent: 5306809 (1994-04-01), Boon et al.
patent: 5554147 (1996-09-01), Batich et al.
patent: 5607417 (1997-03-01), Batich et al.
patent: 5648099 (1997-07-01), Batich et al.
patent: 5654006 (1997-08-01), Fernandez et al.
patent: 5788687 (1998-08-01), Batich et al.
patent: 5952232 (1999-09-01), Rothman
patent: 5955509 (1999-09-01), Webber et al.
patent: 6033888 (2000-03-01), Batich et al.
patent: 6602524 (2003-08-01), Batich et al.
patent: 9513798 (1995-05-01), None
patent: WO 9513798 (1995-05-01), None
patent: 97/04819 (1996-07-01), None
U.S. Appl. No. 60/077,127, Batich et al.
U.S. Appl. No. 09/177,923, Batich et al.
U.S. Appl. No. 09/442,925, Batich et al.
Arshady, R. (1992) “Susponsion, emulsion, and dispersion polymerization: A methodological survey” Colloid Polym Sci 270:717-732.
Hafeli, U. O. et al. (1994) “Magnetically directed poly(lactic acid)ooY-microspheres: Novel agents for targoted intracavilary radiotherapy” Journal of Biomedical Materials Research 28:901-008.
Jahde, E. et al. (1982) “Tumor-selective Modification of Cellular Microenvironment In Vivo: Effect of Glucose Infusion on the pH in Normal and Malignant Rat Tissues1” Cancer Research 42:1505-1512.
Kato, T. et al. (1981) “Arterial Chomoembolization With Microencapsulated Anticancer Drug” JAMA 245(11):1123-1127.
Lin, D. et al. (1988) “Hepatic Arterial Embolization in Patients with Unresoclable Hepalocellular Carcinoma—A Randomized Controlled Trial” Gastroonterology 94:453-456.
Meade, V. M. et al. (1987) “Distribution of Different Sized Microspheres in Experimental Hepatic Tumours” Eur. J. Cancer Clin. Oncol. 23(1):37-41.
Narayanl, R. et al. (1995) “pH-Responsive Gelatin Microspheres for Oral Delivery of Anticancer Drug Molholrexale” J. App. Polym. Sci. 58:1761-1769.
Spanlehauer, G. et al. (1988) “Formation and Characterization of Cisplotin Loaded Poly(d, l-Lactide) Microspheres for Chemoembolization” J. Pharm. Sci. 75(8):750-755.
Volk, T. et al. (1993) “pH in human tumour xenagrafts: effect of intravenous administration of glucose” Br. J. Cancer 68:492-500.
Baker, M.A. et al. “Zyn-linked colchicines: Controlled-release lipophilic prodrugs with enhanced antitumor efficacy”Journal of Controlled Releaso, 1996, 40:89-100.
Bhallacharya, S. et al. “Iodized oil in the treatment of hepatocellular carcinoma”British J. Surgery, 1994. 81:1563-1571.
Ichlhara, T. et al. “Transcatheler Arterial Chemoemboltzation Therapy for Hepatocellular Carcinoma Using Polylactic Acid Microsphers Containing Aclarubicin Hydrochloride”Cancer Research, Aug. 1, 1989, 49:4357-4362.
Leckey, A. “Active Microspheres for Use in the Treatment Hepatic Tumors” A thesis presented to the graduate school of the University of Florida in partial fulfillment of the requirements for the degree of Master of Science, 1997.
Ksontini, R. et al. “Regional Therapy for Liver Tumors: A Novel Embolic Agent and Drug Delivery System” UF Shands Cancer Center GI Cancer Letter, Winter 1997, vol. 4, No. 1.
Arshady, R. (1992) “Susponsion, emulsion, and disporsion polymerization: A methodological survey” Colloid Polym Sci 270:717-732.
Batich Christopher D.
Leckey Adam
Vauthey J. Nicolas
Hartley Michael
Saliwanchik Lloyd & Saliwanchik
University of Florida
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