Microspheres for the controlled release of water-soluble substan

Details Microspheres for the controlled release of water-soluble substan Microspheres for the controlled release of water-soluble substan

1995-07-26

1997-03-11

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 125, 424 133, 424426, 424462, 424486, 42721336, 42840221, 514963, A61K 916, A61K 950, B01J 1302, B32B 516

Patent

active

056098863

ABSTRACT:
Microspheres which are a matrix of a biocompatible and biodegradable polymer which is soluble in an organic solvent which is immiscible in water, within which a water-soluble substance is uniformly distributed, and wherein the residual level of toxic solvent in the microspheres is lower than 1.5% by weight, progressively and continuously releases the substance over a period of at least 8 days when the microspheres are placed in an aqueous physiological environment, with a reduced or substantially absent first phase of accelerated release. A process for producing such microspheres is provided.

REFERENCES:
patent: 3887538 (1975-06-01), Schields et al.
patent: 4384975 (1983-05-01), Fong
patent: 4492720 (1985-01-01), Mosier
patent: 4637905 (1987-01-01), Gardner
patent: 4711782 (1987-12-01), Okada et al.
patent: 4863970 (1989-09-01), Patel et al.
patent: 5100669 (1992-03-01), Hyon et al.
patent: 5232707 (1993-08-01), Lokensgard
patent: 5478564 (1995-12-01), Wantier et al.

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