Microsphere reservoirs for controlled release application

Details Microsphere reservoirs for controlled release application Microsphere reservoirs for controlled release application

1996-10-24

1998-03-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

424401, 424450, A61K 952

Patent

active

057258694

ABSTRACT:
Microspheres, optionally containing an ingredient to be dispensed through controlled release, are prepared by solvent evaporation of an oil-in-water emulsion formed from an organic solvent containing a polymer and a plasticizer and an aqueous solution containing one or more emulsifying agents. The microcapsules formed have a size of between about 3 and about 300 microns in diameter and are porous and spongy in structure as opposed to the hollow core, relatively solid surface structure of microspheres formed by solvent evaporation without utilizing a plasticizer. The microspheres can have a relatively high loading rate of an ingredient to be dispensed combined with a relatively low release rate and are useful for instance for agricultural chemicals, pharmaceuticals or medicines, cosmetics or fragrances.

REFERENCES:
patent: 4780320 (1988-10-01), Baker
patent: 5064949 (1991-11-01), Steiner
patent: 5288502 (1994-02-01), McGinty et al.
Ghebre-Sallassie et al,. Pharmaceutical Technology p. 97, Sep. 1988.
Itoh et al., Chem. Pharm. Bull. 28, 2816 (1980).
Sakellariou et al., J. Controlled Release 7, 147 (1988).
Safwat et al., J. Controlled Release 9, 65 (1989).
Benita et al., J. Controlled Release 12, 213 (1990.
Watts et al., J. Controlled Release 16, 311 (1991).
Moldenhauer et al., J. Controlled Release 17, 49 (1991).
Tefft et al., Proc. Intern. Symp. Control. Rel. Bioact. Mater. 19, 1992.
Lohmann, Proc. Intern. Symp. Control, Rel. Bioact. Mater. 19, 170 (1992).

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