Microsomal triglyceride transfer protein

Details Microsomal triglyceride transfer protein Microsomal triglyceride transfer protein

1995-06-07

1998-08-04

Elliott, George C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 15, 4353201, 530350, 536 235, C12P 2102, C07K 1400, C12Q 100, C12Q 125

Patent

active

057891974

ABSTRACT:
Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

REFERENCES:
Wetterau et al. "Protein Disulfide Isomerase is a Component of the Microsomal Triglyceride Transfer Protein Complex", The Journal of Biological Chemistry, vol. 265, No. 17, pp. 9800-9807, Jun. 15, 1990.

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