Microsomal signal peptidase subunit

Details Microsomal signal peptidase subunit Microsomal signal peptidase subunit

1997-03-26

1999-11-16

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 4353201, 435325, 536 231, 536 232, 536 2431, C12N 948, C12N 1500, C12N 500, C12P 2106

Patent

active

059856386

ABSTRACT:
The present invention provides a human microsomal signal peptidase subunit (HMSP) and polynucleotides which encode HMSP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HMSP.

REFERENCES:
Kalies, K. et al., "Membrane Topology of the 12-and the 25-kDa Subunits of the Mammalian Signal Peptidase Complex" J. Biol. Chem. 271(7): 3925-3929 (1996).
Shelness, G.S. et al., "Two Subunits of the Canine Signal Peptidase Complex Are Homologous to Yeast SEC11 Protein" J. Biol. Chem. 265(16): 9512-9519 (1990) (GI 164081, GI 164082).
van Dijl, J.M. et al., "Identification of the Potential Active Site of the Signal Peptidase SipS of Bacillus subtilis" J. Biol. Chem. 270(8): 3611-3618 (1995).
Signs, S.A. et al., "Induction of ethanol dependence increases signal peptidase mRNA levels in rat brain" Mol. Cell. Biochem. 139: 21-26 (1994) (GI 206977, GI 206978).

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