Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1976-09-20
1977-10-11
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
128260, 424 14, 424 16, 424 19, 424 22, A61K 900, A61K 952, A61K 4700
Patent
active
040535800
ABSTRACT:
The present invention is concerned with a pharmaceutical delivery device comprising a biologically acceptable silicone polymer matrix having microsealed compartments of 10-200 microns throughout, wherein the microsealed compartments contain a pharmaceutical in a hydrophilic solvent system. The biologically acceptable silicone polymer matrix is formed by in situ cross linking of a liquid, biologically acceptable silicone polymer in an emulsion of pharmaceutical in the hydrophilic solvent system and liquid biologically acceptable silicone polymer. The biologically acceptable silicone polymer matrix is placed in a sealed or unsealed biologically acceptable polymer container. The rate of release of pharmaceutical is controlled by altering the solubility characteristics of the hydrophilic solvent system and/or the biologically acceptable polymer matrix, the rate of release being independent of the time when the ratio of the partition coefficient of the pharmaceutical between the hydrophilic solvent system and biologically acceptable silicone polymer matrix to the solubility of the pharmaceutical in the hydrophilic solvent system is between 1 and 10.sup.-4 ml/mcg.
REFERENCES:
patent: 3279996 (1966-10-01), Long et al.
patent: 3518340 (1970-06-01), Raper
patent: 3545439 (1970-12-01), Duncan
patent: 3710795 (1973-01-01), Higuchi et al.
patent: 3797485 (1974-03-01), Urquhart
patent: 3832458 (1974-08-01), Merrill
patent: 3845761 (1974-11-01), Zaffaroni
patent: 3946106 (1976-03-01), Chien et al.
patent: 3992518 (1976-11-01), Chien et al.
Chien Yie W.
Lambert Howard J.
G. D. Searle & Co.
McDonnell John J.
Rose Shep K.
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