Microprocessor system for quantitative chromatographic data anal

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364571, G06F 1520

Patent

active

044687427

ABSTRACT:
Quantitative chromatography is widely used in many fields to measure the amount of a compound present in a mixture. A series of Gaussian-like peaks are generated as output, and the size is conventionally measured by peak area or peak height determinations. The microprocessor-based analysis system of the present invention is designed to "learn" the characteristics of a set of chromatographic peaks. Retention time and peak width parameters are used to detect and measure selected peaks by a convolution procedure based on a matched filter. The filter is applied to peaks in the neighborhood of selecting peak times which have a shape closely resembling that of a control sample. The system is built around a microprocessor with a wide dynamic range analog-to-digital conversion input stage. Operator interaction with the programs and the printing of output results is facilitated.

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patent: 4229968 (1980-10-01), Muldoon
patent: 4338811 (1982-07-01), Miyagi et al.
patent: 4357668 (1982-11-01), Schwartz et al.

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