Microprecipitation of nanoparticulate pharmaceutical agents

Details Microprecipitation of nanoparticulate pharmaceutical agents Microprecipitation of nanoparticulate pharmaceutical agents

1995-01-10

1996-10-01

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424488, 424490, 424 94, 424 95, A61K 914

Patent

active

055609325

ABSTRACT:
This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the presence of a suitable surface-modifying, surface-active agent to form a fine particle dispersion of the said pharmaceutical agent. This can be preferably followed by steps of diafiltration clean-up of the dispersion and then concentration of it to a desired level. This process of dispersion preparation leads to microcrystalline particles of Z-average diameters smaller than 400 nm as measured by photon correlation spectroscopy. Various modification of precipitation schemes are described, many of which are suitable for large-scale manufacture of these agent dispersions.

REFERENCES:
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4250113 (1981-02-01), Nordal et al.
patent: 4396598 (1983-08-01), Lin
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 4713249 (1987-12-01), Schroder
patent: 4725442 (1988-02-01), Haynes
patent: 4826689 (1989-05-01), Violanto et al.
patent: 5118528 (1992-06-01), Fessi et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5260478 (1993-11-01), Bacon et al.
patent: 5264610 (1993-11-01), Bacon
Radiology, Jan. 1982, vol. 142, pp. 115-118.
"International Journal of Pharmaceutics", 52 (1989) 101-108.
Lachman, et al, "The Theory and Practice of Industrial Pharmacy", Chapter 2, Milling, p. 45, (1986).
Investigative Radiology, vol. 19, Jul.-Aug. 1984.
Handbook of Experimental Pharmacology, pp. 56-73, 1984.

Affiliated with

Also associated with

Rating

Microprecipitation of nanoparticulate pharmaceutical agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microprecipitation of nanoparticulate pharmaceutical agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microprecipitation of nanoparticulate pharmaceutical agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1500666