Microporous powder form polylactides

Details Microporous powder form polylactides Microporous powder form polylactides

1985-07-31

1987-02-24

Schoffer, Joseph L.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

528354, 528491, A61K 3174, C08G 6308

Patent

active

046456643

ABSTRACT:
A microporous powder form polylactide which can take up a multiple of its own weight of active material and which can be used for the controlled release of that active material. The aforesaid microporous polylactide powder can be prepared by dissolving polylactide under warming in phthalicacid diethylester, preferably at a temperature over 150.degree. C. and then slowly cooling the clear solution. The resulting suspension is then subjected to filtering and any remain phthalicacid diethylester preferably removed by extraction. The microporous powder recovered is especially suitable for applying thereto therapeutically active substances for controlled release therefrom and is particularly suitable for utilization in veterinary and human medicine. The microporous powder in this form can be introduced into the body subcutaneously, intramuscularly and intraperitoneally.

REFERENCES:
patent: 4137921 (1979-02-01), Okuzumi et al.
patent: 4157437 (1979-06-01), Okuzumi et al.
patent: 4247498 (1981-01-01), Castro
Polymer 1979, vol. 20, pp. 1459-1464.

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