Microporous hollow fiber blood oxygenator

Details Microporous hollow fiber blood oxygenator Microporous hollow fiber blood oxygenator

1998-03-23

2002-02-26

Sykes, Angela D. (Department: 3762)

Chemical apparatus and process disinfecting, deodorizing, preser

Blood treating device for transfusible blood

Oxygenator

C422S048000, C422S044000, C604S004010, C604S006140, C261SDIG002

Reexamination Certificate

active

06350411

ABSTRACT:

FIELD OF THE INVENTION
The present invention is directed to the use of a thick walled microporous hollow fiber membrane in a blood oxygenator.
BACKGROUND OF THE INVENTION
Blood oygenators, as used herein, refers to the medical device that is used to maintain oxygen levels in the blood during surgery, for example heart by-pass surgery. A popular blood oxygenator uses microporous hollow fibers as the interface between the oxygen and the blood. See, for example, U.S. Pat. Nos. 5,489,413; 5,152,964; European Application Publication 507,722; 713,709.
In the use of these devices, ‘plasma leakage’ or ‘plasma breakthrough’ may be a problem. See: Tamari, Yehuda, et. al., “The Effect of High Pressure on Microporous Membrane Oxygenator Failure”,
Artificial Organs,
Vol. 15, No. 1, pg. 15-22, (1991); and Montoya, J.P., et al., “Plasma Leakage Through Microporous Membranes,”
ASAIO Journal,
Vol. 38 pg. M399-405(1992). Plasma leakage is the movement of liquid through the micropores of the membrane from the blood side to the gas side of the device.
Accordingly, there is a need to improve the plasma breakthrough of microporous hollow fiber membranes.
The microporous hollow fiber membrane used herein are disclosed in U.S. Pat. No. 5,695,545. Other known hollow fibers are disclosed in U.S. Pat. Nos. 4,564,488; 4,530,809; 4,859,535; & 5,547,756.
SUMMARY OF THE INVENTION
The present invention is to a process for blood oxygenation using a microporous fiber membrane. The use of the hollow fiber allows improvements in plasma break through results. The oxygenator includes a housing and microporous membrane cartridge. The cartridge comprises a microporous hollow fiber membrane having a wall thickness greater than 30 microns and a bubble point of ≧150 psig.


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Montoya, J.P., et al. ASAIO Journal, vol. 38 p. M399-M405 (1992).

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