Microporous articles comprising biodegradable medical...

Details Microporous articles comprising biodegradable medical... Microporous articles comprising biodegradable medical...

2011-08-30

2011-08-30

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C521S050000, C521S061000, C424S423000, C623S001380, C623S001390

Reexamination Certificate

active

08007823

ABSTRACT:
The present invention relates to a highly controlled method of preparation of a microporous biodegradable polymeric article. Firstly, at least one biodegradable polymer A, one polymer B, biodegradable or not, partially or totally immiscible with A, and a compatibilizer C for A and B are selected. Secondly, the selected polymers are melt-blended, thereby preparing a polymer blend, wherein said polymers A and B have an essentially continuous morphology. Thirdly, after cooling, polymer B and compatibilizer C are selectively extracted from the polymer blend by dissolution in a solvent that is a non-solvent of polymer A. The resulting polymeric article has an essentially continuous porosity with a void volume between 10 and 90% and a unimodal diameter distribution set to a predefined unimodal peak location. It can be used in tissue engineering, for controlled release applications or as an implantable medical device.

REFERENCES:
patent: 4186448 (1980-02-01), Brekke
patent: 4702917 (1987-10-01), Schindler
patent: 4721732 (1988-01-01), Dubrow et al.
patent: 4822678 (1989-04-01), Brody et al.
patent: 4859715 (1989-08-01), Dubrow et al.
patent: 5102983 (1992-04-01), Kennedy
patent: 5133755 (1992-07-01), Brekke
patent: 5290494 (1994-03-01), Coombes et al.
patent: 5492697 (1996-02-01), Boyan et al.
patent: 5502092 (1996-03-01), Barrows et al.
patent: 5514378 (1996-05-01), Mikos et al.
patent: 5522895 (1996-06-01), Mikos
patent: 5567612 (1996-10-01), Vacanti et al.
patent: 5607474 (1997-03-01), Athanasiou et al.
patent: 5677355 (1997-10-01), Shalaby et al.
patent: 5686091 (1997-11-01), Leong et al.
patent: 5711960 (1998-01-01), Shikinami
patent: 5716413 (1998-02-01), Walter et al.
patent: 5723508 (1998-03-01), Healy et al.
patent: 5755792 (1998-05-01), Brekke
patent: 5769899 (1998-06-01), Schwartz et al.
patent: 5770193 (1998-06-01), Vacanti et al.
patent: 5856367 (1999-01-01), Barrows et al.
patent: 5863297 (1999-01-01), Walter et al.
patent: 5866155 (1999-02-01), Laurencin et al.
patent: 5869080 (1999-02-01), McGregor et al.
patent: 5969020 (1999-10-01), Shalaby et al.
patent: 6013853 (2000-01-01), Athanasiou et al.
patent: 6103255 (2000-08-01), Levene et al.
patent: 6203573 (2001-03-01), Walter et al.
patent: 6245345 (2001-06-01), Swanbom et al.
patent: 6281256 (2001-08-01), Harris et al.
patent: 6281257 (2001-08-01), Ma et al.
patent: 6333029 (2001-12-01), Vyakarnam et al.
patent: 6334968 (2002-01-01), Shapiro et al.
patent: 6337198 (2002-01-01), Levene et al.
patent: 6355699 (2002-03-01), Vyakarnam et al.
patent: 6365149 (2002-04-01), Vyakarnam et al.
patent: 6511511 (2003-01-01), Slivka et al.
patent: 2002/0005600 (2002-01-01), Ma
patent: 2002/0102674 (2002-08-01), Anderson
patent: 0 246 752 (1987-11-01), None
patent: 0 283 187 (1988-09-01), None
Washburn, N.R. et al., Journal of Biomedical Materials Research, 2002, vol. 60, No. 1, pp. 20-29.

Affiliated with

Also associated with

Rating

Microporous articles comprising biodegradable medical... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microporous articles comprising biodegradable medical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microporous articles comprising biodegradable medical... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2744291