Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Patent
1998-12-09
2000-11-07
Smith, Ruth S.
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
600365, 600573, 601 2, 604290, 606 9, 606131, 607 96, A61B 500
Patent
active
061429392
ABSTRACT:
A method of enhancing the permeability of the skin to an analyte for diagnostic purposes or to a drug for therapeutic purposes is described utilizing microporation and optionally sonic energy and a chemical enhancer. If selected, the sonic energy may be modulated by means of frequency modulation, amplitude modulation, phase modulation, and/or combinations thereof. Microporation is accomplished by (a) ablating the stratum corneum by localized rapid heating of water such that such water is vaporized, thus eroding the cells; (b) puncturing the stratum corneum with a micro-lancet calibrated to form a micropore of up to about 1000 .mu.m in diameter; (c) ablating the stratum corneum by focusing a tightly focused beam of sonic energy onto the stratum corneum; (d) hydraulically puncturing the stratum corneum with a high pressure jet of fluid to form a micropore of up to about 1000 .mu.m in diameter, or (e) puncturing the stratum corneum with short pulses of electricity to form a micropore of up to about 1000 .mu.m in diameter. A dye with an absorption maximum matched to the wavelength of a pulsed light source can be absorbed into the stratum corneum to concentrate the energy of the pulsed light source and aid in ablation of the stratum corneum. Alternatively, a hot wire can be caused to contact the stratum corneum.
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Eppstein Jonathan A.
Hatch Michael R.
Yang Difei
Altea Technologies, Inc.
Smith Ruth S.
SpectRx, Inc.
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